GPCR large-amplitude dynamics by 19F-NMR of aprepitant bound to the neurokinin 1 receptor
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122682119
Abstract: Significance G protein-coupled receptor (GPCR) structures determined by X-ray crystallography or cryo-electron microscopy include 28 receptors for which complexes with agonists and antagonists can be compared. In all these comparisons, an interatomic distance representing the… read more here.
Keywords: receptor gpcr; large amplitude; 19f nmr; aprepitant ... See more keywords
Evidences of G-Coupled Protein Receptor (GPCR) signaling in the human malaria parasite Plasmodium falciparum for sensing its microenvironment and the role of purinergic signaling in malaria parasites..
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200826122716
Abstract: The nucleotides were discovered in the early 19th century and a few years later the role of such molecules in the energy metabolism and cell survival was postulated. In 1972 a pioneer work by Burnstock… read more here.
Keywords: protein receptor; evidences coupled; receptor gpcr; gpcr signaling ... See more keywords
Structural Characterization of Receptor–Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063241
Abstract: G protein-coupled receptor (GPCR) oligomerization, while contentious, continues to attract the attention of researchers. Numerous experimental investigations have validated the presence of GPCR dimers, and the relevance of dimerization in the effectuation of physiological functions… read more here.
Keywords: receptor gpcr; protein coupled; coupled receptor; gpcr ... See more keywords