Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01238-5
Abstract: In fragile X syndrome (FXS) the lack of the fragile X mental retardation protein (FMRP) leads to exacerbated signaling through the metabotropic glutamate receptors 5 (mGlu5Rs). The adenosine A 2A receptors (A 2A Rs), modulators… read more here.
Keywords: fmr1 mice; inhibition reduces; receptor inhibition; adenosine a2a ... See more keywords
Immune receptor inhibition through enforced phosphatase recruitment
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DOI: 10.1038/s41586-020-2851-2
Abstract: Antibodies that antagonize extracellular receptor–ligand interactions are used as therapeutic agents for many diseases to inhibit signalling by cell-surface receptors 1 . However, this approach does not directly prevent intracellular signalling, such as through tonic… read more here.
Keywords: receptor; cell surface; cell; receptor inhibition ... See more keywords
Daidzein is the in vivo active compound of Puerariae Lobatae Radix water extract for muscarinic receptor-3 inhibition against overactive bladder
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.924251
Abstract: Background: In the previous study, Puerariae Lobatae Radix (named Gegen in Chinese) water extract attenuated M3 receptor agonist carbachol-induced detrusor contraction after 3-week oral administration in a hypertension-associated OAB (overactive bladder) model. This research aimed… read more here.
Keywords: receptor inhibition; receptor; water extract; inhibition ... See more keywords