Melatonin, a toll‐like receptor inhibitor: Current status and future perspectives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27698
Abstract: Toll‐like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a… read more here.
Keywords: melatonin toll; toll like; receptor inhibitor; like receptor ... See more keywords
Clinical Pharmacokinetics of the Androgen Receptor Inhibitor Darolutamide in Healthy Subjects and Patients with Hepatic or Renal Impairment
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-021-01078-y
Abstract: Darolutamide is a second-generation androgen receptor inhibitor approved for the treatment of nonmetastatic castration-resistant prostate cancer at a dosage of 600 mg orally twice daily. We aimed to fully characterize the pharmacokinetic profile of darolutamide,… read more here.
Keywords: androgen receptor; healthy subjects; renal impairment; receptor inhibitor ... See more keywords
Effects of the androgen receptor inhibitor enzalutamide on the pharmacokinetics of dolutegravir and tenofovir: a case report.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS"
DOI: 10.1097/qad.0000000000003269
Abstract: ABSTRACT Enzalutamide is an androgen receptor inhibitor used for the treatment of prostate cancer. Although enzalutamide causes a favorable adverse effect profile, it might cause drug-drug interactions with some antiretrovirals. No major differences on the… read more here.
Keywords: receptor inhibitor; androgen receptor; case report; dolutegravir tenofovir ... See more keywords
Long-term use and remission of granulomatosis with polyangiitis with the oral C5a receptor inhibitor avacopan
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Case Reports"
DOI: 10.1136/bcr-2020-236236
Abstract: Granulomatosis with polyangiitis (GPA) is a rare antineutrophil cytoplasm antibody-associated vasculitis. Several therapeutic advances have occurred over the past two decades, but relapse rate remains high and refractory cases are not uncommon. Here, we present… read more here.
Keywords: receptor inhibitor; granulomatosis polyangiitis; c5a receptor;
TGF-β receptor I inhibitor may restrict the induction of EMT in inflamed intestinal epithelial cells.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental biology and medicine"
DOI: 10.1177/15353702231151959
Abstract: Despite the extensive body of research, understanding the exact molecular mechanisms governing inflammatory bowel diseases (IBDs) still demands further investigation. Transforming growth factor-β1 (TGF-β1) signaling possesses a multifacial effect on a broad range of context-dependent… read more here.
Keywords: emt; tgf receptor; receptor inhibitor; epithelial cells ... See more keywords