Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108648
Abstract: Receptor-interacting protein 2 (RIP2) is a kinase that is involved in downstream signaling of nuclear oligomerization domain (NOD)-like receptors NOD1 and 2 sensing bacterial peptidoglycans. RIP2-deficiency or targeting of RIP2 by pharmaceutical inhibitors partially ameliorates… read more here.
Keywords: receptor interacting; interacting protein; autoinflammation immunity; protein rip2 ... See more keywords
Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00604
Abstract: Receptor-interacting serine/threonine protein kinase 2 (RIPK2) has been demonstrated to be a promising target for treating inflammatory diseases. Herein, we describe the discovery and optimization of a series of RIPK2 inhibitors derived from an FLT3… read more here.
Keywords: protein kinase; kinase ripk2; receptor interacting; interacting serine ... See more keywords
Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01478
Abstract: Receptor-interacting protein kinase 1 (RIPK1) contributes to a broad set of inflammations and necroptosis in human diseases, which also plays an important role in the pathogenesis of Alzheimer's disease (AD). The inhibition of RIPK1 could… read more here.
Keywords: protein kinase; receptor interacting; alzheimer disease; interacting protein ... See more keywords
Expression and anti-inflammatory role of activin receptor-interacting protein 2 in lipopolysaccharide-activated macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10855-4
Abstract: The bacterial endotoxin lipopolysaccharide (LPS), a key pathogenic stimulator, can induce the activation of macrophages. Activin receptor-interacting protein 2 (ARIP2), an intracellular signaling protein, has a wide histological distribution, however, whether ARIP2 is involved in… read more here.
Keywords: receptor interacting; anti inflammatory; inflammatory role; expression ... See more keywords
The Receptor Interacting Protein Kinases in the Liver.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in liver disease"
DOI: 10.1055/s-0038-1629924
Abstract: The receptor interacting serine/threonine kinase1 and 3 (RIPK1, RIPK3) are regulators of cell death and survival. RIPK1 kinase activity is required for necroptosis and apoptosis, while its scaffolding function is necessary for survival. Although both… read more here.
Keywords: receptor interacting; death; ripk1 ripk3; cell death ... See more keywords
Receptor-interacting protein kinase 1 (RIPK1) inhibitor: a review of the patent literature (2018-present)
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2023.2195548
Abstract: ABSTRACT Introduction RIPK1 is a critical mediator of inflammation and cell death, which is associated with extensive neurodegenerative and inflammatory diseases. Recently, RIPK1 has aroused the interests of pharmaceutical industry and research institutions. Areas covered… read more here.
Keywords: receptor interacting; review; ripk1 inhibitors; ripk1 ... See more keywords
Inhibition of microglial receptor‐interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15820
Abstract: Microglia are rapidly activated following ischaemic stroke and participate in the induction of neuroinflammation, which exacerbates the injury of ischaemic stroke. However, the mechanisms regulating ischaemic microglia remain unclear. In the present study, middle cerebral… read more here.
Keywords: receptor interacting; ripk1; neuroinflammation; ischaemic stroke ... See more keywords
Roles of receptor‐interacting protein kinase 1 in SH‐SY5Y cells with beta amyloid‐induced neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17095
Abstract: Alzheimer's disease (AD), the major cause of dementia, affects the elderly population worldwide. Previous studies have shown that depletion of receptor‐interacting protein kinase 1 (RIPK1) expression reverted the AD phenotype in murine AD models. Necroptosis,… read more here.
Keywords: beta amyloid; receptor interacting; protein kinase; interacting protein ... See more keywords
Receptor‐interacting protein 3‐phosphorylated Ca2+/calmodulin‐dependent protein kinase II and mixed lineage kinase domain‐like protein mediate intracerebral hemorrhage‐induced neuronal necroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15731
Abstract: Necroptosis‐mediated cell death is an important mechanism in intracerebral hemorrhage (ICH)‐induced secondary brain injury (SBI). Our previous study has demonstrated that receptor‐interacting protein 1 (RIP1) mediated necroptosis in SBI after ICH. However, further mechanisms, such… read more here.
Keywords: necroptosis; receptor interacting; interacting protein; mlkl camk ... See more keywords
Loss of receptor interacting protein kinases 3 and caspase‐8 augments intrinsic apoptosis in tubular epithelial cell and promote kidney ischaemia‐reperfusion injury
Sign Up to like & getrecommendations! Published in 2019 at "Nephrology"
DOI: 10.1111/nep.13487
Abstract: Ischaemia‐reperfusion injury (IRI) is associated with programmed cell death that promotes inflammation and organ dysfunction. Necroptosis is mediated by members of receptor interacting protein kinases (RIPK1/3). Inhibition of RIPK1/3 provides a pro‐survival benefit in kidney… read more here.
Keywords: receptor interacting; protein kinases; ischaemia reperfusion; reperfusion injury ... See more keywords
Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Stroke"
DOI: 10.1161/strokeaha.117.017702
Abstract: Background and Purpose— Recent studies using cultured cells and rodent intracerebral hemorrhage (ICH) models have implicated RIPK1 (receptor interacting protein kinase-1) as a driver of programmed necrosis and secondary injury based on use of chemical… read more here.
Keywords: receptor interacting; death; intracerebral hemorrhage; kinase ... See more keywords