Muscle‐restricted nuclear receptor interaction protein knockout causes motor neuron degeneration through down‐regulation of myogenin at the neuromuscular junction
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12299
Abstract: Nuclear receptor interaction protein (NRIP) is a calcium/calmodulin (CaM) binding protein. Nuclear receptor interaction protein interacts with CaM to activate calcineurin and CaMKII signalling. The conventional NRIP knockout mice (global knockout) showed muscular abnormality with… read more here.
Keywords: interaction protein; receptor interaction; nuclear receptor;
The Innovative Role of Nuclear Receptor Interaction Protein in Orchestrating Invadosome Formation for Myoblast Fusion
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13598
Abstract: Nuclear receptor interaction protein (NRIP) is versatile and engages with various proteins to execute its diverse biological function. NRIP deficiency was reported to cause small myofibre size in adult muscle regeneration, indicating a crucial role… read more here.
Keywords: myoblast fusion; interaction protein; nuclear receptor; receptor interaction ... See more keywords
Connectome-constrained ligand-receptor interaction analysis for understanding brain network communication
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DOI: 10.1038/s41467-025-63204-9
Abstract: Both diffusion magnetic resonance imaging and transcriptomic technologies have provided unprecedented opportunities to dissect brain network communication, offering insights from structural connectivity and signaling molecules separately. However, incorporating these complementary modalities for characterizing the interregional… read more here.
Keywords: communication; receptor interaction; brain; ligand receptor ... See more keywords
Decoding functional impact of epigenetic regulator mutations on ligand–receptor interaction perturbations for evaluation of cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70009
Abstract: Cellular crosstalk mediated by ligand–receptor interactions largely complicates the tumour ecosystem, resulting in heterogeneous tumour microenvironments that affect immune response and clinical benefits from immunotherapy. Epigenetic mechanisms are pivotal to expression changes of immune‐related genes… read more here.
Keywords: receptor; cancer; mutations ligand; ligand receptor ... See more keywords
Importance of the ECM–receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis
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DOI: 10.1111/mec.17352
Abstract: Low dissolved oxygen (LO) conditions represent a major environmental challenge to marine life, especially benthic animals. For these organisms, drastic declines in oxygen availability (hypoxic events) can trigger mass mortality events and thus, act as… read more here.
Keywords: receptor interaction; ecm receptor; transcription translation; hypoxia ... See more keywords
Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases
Sign Up to like & getrecommendations! Published in 2024 at "Military Medical Research"
DOI: 10.1186/s40779-024-00564-1
Abstract: Nuclear receptors (NRs) function as crucial transcription factors in orchestrating essential functions within the realms of development, host defense, and homeostasis of body. NRs have garnered increased attention due to their potential as therapeutic targets,… read more here.
Keywords: interaction emerging; treatment; tackling exosome; nuclear receptor ... See more keywords
Eucommia ulmoides Oliver-Tribulus terrestris L. Drug Pair Regulates Ferroptosis by Mediating the Neurovascular-Related Ligand-Receptor Interaction Pathway- A Potential Drug Pair for Treatment Hypertension and Prevention Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.833922
Abstract: Background In this study, we used the network pharmacology approach to explore the potential disease targets of the Eucommia ulmoides Oliver (EUO)-Tribulus terrestris L. (TT) drug pair in the treatment of hypertension-associated neurovascular lesions and… read more here.
Keywords: ligand receptor; drug pair; receptor interaction; drug ... See more keywords