Characterization of Ligand-Receptor Interactions: Chemotaxis, Biofilm, Cell Culture Assays, and Animal Model Methodologies.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6536-6_13
Abstract: Chemotactic motility is an essential virulence factor for the pathogenesis of Campylobacter spp. infection. In Chapter 6 , we described technologies that enable initial screening and identification of ligands able to interact with chemoreceptor sensory… read more here.
Keywords: receptor interactions; biofilm; ligand receptor; characterization ligand ... See more keywords
Analysis of Ethylene Receptor Interactions by Co-immunoprecipitation Assays.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6854-1_9
Abstract: Ethylene receptors are predominantly localized to the endoplasmic reticulum (ER) membrane, and coordinate ethylene signal output through protein-protein interactions with each other and additional signaling components. Here, we describe a co-immunoprecipitation (Co-IP) assay based on… read more here.
Keywords: receptor interactions; ethylene; analysis ethylene; ethylene receptors ... See more keywords
Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor-Receptor Interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.08.009
Abstract: Dysregulation of tumor necrosis factor (TNF) receptor signaling is a key feature of various inflammatory disorders. Current treatments for TNF-related diseases function either by sequestering ligand or blocking ligand-receptor interactions, which can cause dangerous side… read more here.
Keywords: receptor interactions; death receptor; apoptosis; receptor ... See more keywords
Probing Ion-Receptor Interactions in Halide Complexes of Octamethyl Calix[4]Pyrrole.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c13445
Abstract: Ion receptors are molecular hosts that bind ionic guests, often with great selectivity. The interplay of solvation and ion binding in anion host-guest complexes in solution governs the binding efficiency and selectivity of such ion… read more here.
Keywords: ion receptor; octamethyl calix; ion; receptor interactions ... See more keywords
Finding spatially variable ligand-receptor interactions with functional support from downstream genes
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DOI: 10.1038/s41467-025-62988-0
Abstract: Spatial transcriptomics has emerged as a groundbreaking tool for the study of intercellular ligand-receptor interactions (LRIs) that exhibit spatial variability. To identify spatially variable LRIs with activation evidence, we present SPIDER, which constructs cell-cell interaction… read more here.
Keywords: spatially variable; cell; receptor interactions; ligand receptor ... See more keywords
Nano-Luciferase complementation assay of human herpesvirus 8 chemo/cytokine-receptor interactions
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DOI: 10.1038/s41598-025-19281-3
Abstract: Some viruses encode proteins that mimic host chemokines and/or cytokines to modulate the host immune responses against infection. Human herpesvirus 8 (HHV-8), also termed Kaposi sarcoma-associated herpesvirus (KSHV), encodes three viral CC-type chemokines (vCCLs 1–3)… read more here.
Keywords: receptor; chemo cytokine; human herpesvirus; receptor interactions ... See more keywords
Chemokine ligand–receptor interactions critically regulate cutaneous wound healing
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Medical Research"
DOI: 10.1186/s40001-017-0299-0
Abstract: BackgroundWound healing represents a dynamic process involving directional migration of different cell types. Chemokines, a family of chemoattractive proteins, have been suggested to be key players in cell-to-cell communication and essential for directed migration of… read more here.
Keywords: receptor interactions; wound healing; ligand receptor; chemokine ligand ... See more keywords
Ligand-Receptor Interactions and Machine Learning in GCGR and GLP-1R Drug Discovery
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22084060
Abstract: The large amount of data that has been collected so far for G protein-coupled receptors requires machine learning (ML) approaches to fully exploit its potential. Our previous ML model based on gradient boosting used for… read more here.
Keywords: receptor interactions; machine learning; drug; ligand receptor ... See more keywords