Insulin Receptor Isoforms in Cancer
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DOI: 10.3390/ijms19113615
Abstract: The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. In many cancers, IR is overexpressed… read more here.
Keywords: cancer; receptor isoforms; isoforms cancer; insulin receptor ... See more keywords
Identification and Pharmacological Characterization of Two Serotonin Type 7 Receptor Isoforms from Mythimna separata
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DOI: 10.3390/ijms24010655
Abstract: Serotonin (5-hydroxytryptamine, 5-HT) is an important neuroactive molecule, as neurotransmitters regulate various biological functions in vertebrates and invertebrates by binding and activating specific 5-HT receptors. The pharmacology and tissue distribution of 5-HT receptors have been… read more here.
Keywords: pharmacology; pharmacological characterization; receptor isoforms; mythimna separata ... See more keywords
Physiological and Pathophysiological Roles of IgM Fc Receptor (FcµR) Isoforms
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DOI: 10.3390/ijms24065728
Abstract: IgM is the first antibody to emerge during phylogeny, ontogeny, and immune responses and serves as a first line of defense. Effector proteins interacting with the Fc portion of IgM, such as complement and its… read more here.
Keywords: pathophysiological roles; roles igm; igm receptor; receptor isoforms ... See more keywords
Thyroid Hormone Receptor Isoforms Alpha and Beta Play Convergent Roles in Muscle Physiology and Metabolic Regulation
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DOI: 10.3390/metabo12050405
Abstract: Skeletal muscle is a key energy-regulating organ, skilled in rapidly boosting the rate of energy production and substrate consumption following increased workload demand. The alteration of skeletal muscle metabolism is directly associated with numerous pathologies… read more here.
Keywords: hormone receptor; muscle; physiology; thyroid hormone ... See more keywords