Mu and delta opioid receptor knockout mice show increased colonic sensitivity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pain"
DOI: 10.1002/ejp.965
Abstract: Opiates act through opioid receptors to diminish pain. Here, we investigated whether mu (MOR) and delta (DOR) receptor endogenous activity assessed in the whole mouse body or in particular at peripheral receptors on primary nociceptive… read more here.
Keywords: opioid receptor; knockout mice; delta opioid; receptor ... See more keywords
Hyperprolactinemia in a male pituitary androgen receptor knockout mouse is associated with female‐like lactotroph development
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DOI: 10.1111/andr.13040
Abstract: Circulating prolactin concentration in rodents and humans is sexually dimorphic. Oestrogens are a well‐characterised stimulator of prolactin release. Circulating prolactin fluctuates throughout the menstrual/oestrous cycle of females in response to oestrogen levels, but remains continually… read more here.
Keywords: pituitary androgen; androgen receptor; prolactin; receptor knockout ... See more keywords
Pharmacological evaluation of pioglitazone and candesartan cilexetil in a novel mouse model of non‐alcoholic steatohepatitis, modified choline‐deficient, amino acid‐defined diet fed low‐density lipoprotein receptor knockout mice
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DOI: 10.1111/hepr.12773
Abstract: Low‐density lipoprotein receptor knockout (LDLR‐KO) mice fed a modified choline‐deficient and amino acid‐defined (mCDAA) diet show non‐alcoholic steatohepatitis (NASH)‐like pathophysiology. In order to pharmacologically benchmark this model, effects of pioglitazone (a thiazolidinedione) and candesartan cilexetil… read more here.
Keywords: density lipoprotein; low density; receptor; modified choline ... See more keywords
Moderate Continuous Aerobic Exercise Training Improves Cardiomyocyte Contractility in Β1 Adrenergic Receptor Knockout Mice
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DOI: 10.5935/abc.20180025
Abstract: Background The lack of cardiac β1-adrenergic receptors (β1-AR) negatively affects the regulation of both cardiac inotropy and lusitropy, leading, in the long term, to heart failure (HF). Moderate-intensity aerobic exercise (MCAE) is recommended as an… read more here.
Keywords: adrenergic receptor; 1arko mice; mice; aerobic exercise ... See more keywords