Two-Dimensional Analysis of Cross-Junctional Molecular Interaction by Force Probes.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6881-7_15
Abstract: Upon engagement with a specific ligand, a cell surface receptor transduces intracellular signals to activate various cellular functions. This chapter describes a set of biomechanical methods for analyzing the characteristics of cross-junctional receptor-ligand interactions at… read more here.
Keywords: receptor ligand; cross junctional; force; receptor ... See more keywords
Sigma-1 receptor ligand PD144418 and sigma-2 receptor ligand YUN-252 attenuate the stimulant effects of methamphetamine in mice
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05268-2
Abstract: RationalePrevious research indicates that the selective sigma-1 receptor ligand PD144418 and the selective sigma-2 ligands YUN-252 can inhibit cocaine-induced hyperactivity. The effects of these ligands on other stimulants, such as methamphetamine, have not been reported.ObjectivesThe… read more here.
Keywords: methamphetamine; receptor ligand; sigma; yun 252 ... See more keywords
Pasireotide—a novel somatostatin receptor ligand after 20 years of use
Sign Up to like & getrecommendations! Published in 2022 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-022-09710-3
Abstract: Pasireotide, a novel multireceptor-targeted somatostatin receptor ligand (SRL) is characterized by a higher affinity to somatostatin receptor type 5 than type 2, unlike first-generation SRLs. Because of the broader binding profile, pasireotide has been suggested… read more here.
Keywords: somatostatin receptor; pasireotide novel; receptor ligand; cushing disease ... See more keywords
BINANA 2: Characterizing Receptor/Ligand Interactions in Python and JavaScript
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.1c01461
Abstract: BINding ANAlyzer (BINANA) is an algorithm for identifying and characterizing receptor/ligand interactions and other factors that contribute to binding. We recently updated BINANA to make the algorithm more accessible to a broader audience. We have… read more here.
Keywords: receptor ligand; characterizing receptor; binana; ligand interactions ... See more keywords
Demystifying P2Y1 Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00528
Abstract: We performed a molecular modeling analysis of 100 nucleotide-like bisphosphates and 46 non-nucleotide arylurea derivatives previously reported as P2Y1R binders using the recently solved hP2Y1R structures. We initially docked the compounds at the X-ray structures… read more here.
Keywords: receptor ligand; molecular dynamics; p2y1 receptor; demystifying p2y1 ... See more keywords
Receptor-Ligand Binding Free Energies from a Consecutive Histograms Monte Carlo Sampling Method.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.0c00457
Abstract: To obtain accurate and converged free energy calculations for ligand binding to biomolecular systems requires validated force fields and extensive sampling of the energy landscape, which requires exhaustive and effective conformational searching methods. Herein, we… read more here.
Keywords: receptor ligand; energy; binding free; ligand binding ... See more keywords
Dichotomous Nature of Bistability Generated by Negative Cooperativity in Receptor-Ligand Binding.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00517
Abstract: Positive cooperativity in receptor-ligand binding plays an important role in cell signaling as it generates an ultrasensitive response, a requirement for nonlinear phenomena such as bistability and oscillations in feedback regulated reaction networks. On the… read more here.
Keywords: receptor ligand; negative cooperativity; bistability; cooperativity ... See more keywords
Manipulating Nanoparticle Aggregates Regulates Receptor-Ligand Binding in Macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c08861
Abstract: The receptor-ligand interactions in cells are dynamically regulated by modulation of the ligand accessibility. In this study, we utilize size-tunable magnetic nanoparticle aggregates ordered at both nanometer and atomic scales. We flexibly anchor magnetic nanoparticle… read more here.
Keywords: ligand binding; nanoparticle aggregates; receptor ligand; ligand ... See more keywords
Novel antitumor copper(II) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj01763h
Abstract: In the present article the 1,4-dioxane derivative 1, a potent noncompetitive NMDA receptor antagonist, showed cytotoxic activity in the MCF7 breast cancer cell line significantly higher than those of the functionally related compounds (S)-(+)-ketamine and… read more here.
Keywords: copper complexes; copper; receptor ligand; nmda receptor ... See more keywords
Interplay between cooperativity of intercellular receptor-ligand binding and coalescence of nanoscale lipid clusters in adhering membranes.
Sign Up to like & getrecommendations! Published in 2021 at "Soft matter"
DOI: 10.1039/d0sm01904f
Abstract: Adhesion of biological cells is mediated by the specific binding of receptors and ligands which are typically large proteins spanning through the plasma membranes of the contacting cells. The receptors and ligands can exhibit affinity… read more here.
Keywords: nanoscale lipid; lipid clusters; receptor ligand; ligand binding ... See more keywords
Reversible dougong structured receptor–ligand recognition for building dynamic extracellular matrix mimics
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117221119
Abstract: Significance This paper reports an exciting breakthrough in dynamic biomaterials design mimicking the reversible interlocking and remoldable structure of extracellular matrix (ECM). Specifically, we realize a nature-derived molecular recognition event (i.e., the antibiotic glycopeptide vancomycin… read more here.
Keywords: recognition; extracellular matrix; receptor ligand;