A brief overview of BNIP3L/NIX receptor-mediated mitophagy.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13307
Abstract: Mitophagy is a form of autophagy specialized to selectively remove mitochondria. Although the PINK1/Parkin pathway is the best described mitophagy of damaged mitochondria, receptor/mediated mitophagy seems to have a pivotal role in cellular development and… read more here.
Keywords: mediated mitophagy; bnip3l nix; brief overview; receptor ... See more keywords
P2X7 receptor‐mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Pain"
DOI: 10.1002/ejp.1951
Abstract: P2X7 receptor antagonists have potential for treating various central nervous system (CNS) diseases, including neuropathic pain, although none have been approved for clinical use. Reasons may include insufficient understanding of P2X7 receptor signalling in pain,… read more here.
Keywords: p2x7 receptor; receptor mediated; release microglial; mediated release ... See more keywords
Adenosine and adenosine receptor-mediated action in coronary microcirculation
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DOI: 10.1007/s00395-021-00859-7
Abstract: Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in the regulation of coronary microcirculation through activation of adenosine receptors (ARs). Adenosine is regulated by various enzymes and nucleoside transporters for its… read more here.
Keywords: adenosine receptor; adenosine adenosine; coronary microcirculation; adenosine ... See more keywords
Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2634-4
Abstract: Glutamate is the primary excitatory neurotransmitter in neurons and glia. N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate receptors are major ionotropic glutamate receptors. Glutamatergic neurotransmission is strongly linked with Ca2+ homeostasis. Research has provided ample… read more here.
Keywords: nmda receptor; senescence; neurotransmission; mediated glutamatergic ... See more keywords
Resveratrol noncompetitively inhibits glycine receptor-mediated currents in neurons of rat central auditory neurons
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.12.021
Abstract: Resveratrol, a naturally occurring stilbene found in red wine, is known to modulate the activity of several types of ion channels and membrane receptors, including Ca2+, K+, and Na+ ion channels. However, little is known… read more here.
Keywords: mediated currents; glycine receptor; currents neurons; receptor ... See more keywords
Biased agonists with less glucagon-like peptide-1 receptor-mediated endocytosis prolong hypoglycaemic effects.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174203
Abstract: Receptor endocytic trafficking entails targeting receptors and ligands to endocytic sites, followed by internalization and sorting to recycling or degradative compartments. Thus, membrane receptor-mediated signalling pathways not only contribute to the efficacy of the drugs… read more here.
Keywords: glucagon like; endocytosis; receptor; glp receptor ... See more keywords
T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.08.009
Abstract: Objective Beyond the taste buds, sweet taste receptors (STRs; T1R2/T1R3) are also expressed on enteroendocrine cells, where they regulate gut peptide secretion but their regulatory function within the intestine is largely unknown. Methods Using T1R2-knock… read more here.
Keywords: absorption; intestine; t1r2 receptor; glucose absorption ... See more keywords
GABAA receptor-mediated networks during focal seizure onset and progression in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2019.02.007
Abstract: Focal seizures are triggered by the pathological synchronization of a functionally altered group of neurons. In vivo and in vitro results in rodents and single unit studies in humans suggest that seizure can be initiated… read more here.
Keywords: mediated networks; gabaa receptor; focal seizure; seizure ... See more keywords
Mechanisms of motor learning mediated by synaptic plasticity in rat primary motor cortex
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DOI: 10.1016/j.neures.2017.09.008
Abstract: Motor skill training induces long-term potentiation (LTP) and structural plasticity at dendritic spines in the primary motor cortex (M1). However, little is known about the plasticity of individual M1 neurons. Skilled motor coordination in rodents… read more here.
Keywords: plasticity; motor; motor cortex; primary motor ... See more keywords
Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.03.032
Abstract: AMPA- and NMDA-type glutamate receptors mediate distinct postsynaptic signals that differ characteristically among synapses. How postsynaptic AMPA- and NMDA-receptor levels are regulated, however, remains unclear. Using newly generated conditional knockin mice that enable genetic control… read more here.
Keywords: neurexin; ampa receptor; nmda ampa; receptor ... See more keywords
Involvement of lateral habenula α1 subunit-containing GABAA receptor-mediated inhibitory transmission in the regulation of depression-related behaviors in experimental Parkinson's disease
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.01.015
Abstract: &NA; The lateral habenula (LHb) plays an important role in the regulation of depression. At present, it is not clear whether GABAA receptor‐mediated inhibitory transmission in the LHb is involved in Parkinson's disease (PD)‐associated depression.… read more here.
Keywords: depression; gabaa receptor; receptor mediated; transmission ... See more keywords