Targeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.70121
Abstract: Type 2 diabetes mellitus (T2D) arises from the interplay between peripheral insulin resistance and pancreatic β‐cell dysfunction, ultimately leading to impaired glucose utilization and chronic hyperglycemia. Despite therapeutic advances, the multifactorial nature of T2D continues… read more here.
Keywords: membrane component; receptor membrane; progesterone receptor; development ... See more keywords
Sigma‐2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma‐2 receptor ligands to PGRMC1
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2016.12.023
Abstract: Graphical abstract Figure. No Caption available. Abstract A controversial relationship between sigma‐2 and progesterone receptor membrane component 1 (PGRMC1) proteins, both representing promising targets for the therapy and diagnosis of tumors, exists since 2011, when… read more here.
Keywords: pgrmc1; progesterone receptor; receptor membrane; sigma ... See more keywords
Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01202-x
Abstract: Progesterone receptor membrane associated component 1 (PGRMC1) exhibits haem-dependent dimerization on cell membrane and binds to EGF receptor and cytochromes P450 to regulate cancer proliferation and chemoresistance. However, its physiological functions remain unknown. Herein, we… read more here.
Keywords: pgrmc1; progesterone receptor; receptor membrane; receptor ... See more keywords