Intracellular Receptor Modulation: Novel Approach to Target GPCRs.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2018.03.002
Abstract: Recent crystal structures of multiple G protein-coupled receptors (GPCRs) have revealed a highly conserved intracellular pocket that can be used to modulate these receptors from the inside. This novel intracellular site partially overlaps with the… read more here.
Keywords: intracellular receptor; approach target; novel approach; modulation novel ... See more keywords
Noradrenergic Receptor Modulation Influences the Acoustic Parameters of Pro-Social Rat Ultrasonic Vocalizations
Sign Up to like & getrecommendations! Published in 2018 at "Behavioral Neuroscience"
DOI: 10.1037/bne0000258
Abstract: Rats produce high rates of ultrasonic vocalizations (USVs) in social situations; these vocalizations are influenced by multiple neurotransmitter systems. Norepinephrine (NE) plays a significant role in vocalization biology; however, the contribution of NE to normal,… read more here.
Keywords: intensity; ultrasonic vocalizations; noradrenergic receptor; rat ... See more keywords
Treatment of chronic neuropathic pain: purine receptor modulation.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001857
Abstract: Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses four G protein-coupled receptors (GPCRs) for adenosine, eight GPCRs activated by nucleotides (P2YRs), seven adenosine 5'-triphosphate(ATP)-gated P2X ion channels, as… read more here.
Keywords: chronic neuropathic; receptor modulation; neuropathic pain; purine receptor ... See more keywords
Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives.
Sign Up to like & getrecommendations! Published in 2018 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2017-0172
Abstract: Activation or inhibition of TLR4 by small molecules will provide in the next few years a new generation of therapeutics. TLR4 stimulation (agonism) by high-affinity ligands mimicking lipid A gave vaccine adjuvants with improved specificity… read more here.
Keywords: toll like; modulation new; advances toll; like receptor ... See more keywords