The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold
Sign Up to like & getrecommendations! Published in 2018 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2018.07.028
Abstract: A convenient approach to novel symmetric bispyrimidine diamines comprises SNAr reactions of 4-fluoropyrimidine N-oxide with alkane-α,ω-diamines with subsequent reduction of N-oxide function. The obtained substances were tested in patch-clamp experiments for the influence on the… read more here.
Keywords: negative modulators; modulators based; receptor negative; ampa receptor ... See more keywords
AGR2 associates with HER2 expression predicting poor outcome in subset of estrogen receptor negative breast cancer patients.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2017.02.016
Abstract: Expression of the AGR2 oncogene was shown to be associated with estrogen receptor positive tumors. This gene contributes to enhanced cellular proliferation, drug resistance, metastasis development and may also serve as a predictor of poor… read more here.
Keywords: subset estrogen; estrogen; receptor negative; expression ... See more keywords
Identification of Triazolopyridines as Selective α5-GABAA Receptor Negative Allosteric Modulators by a Hybridization Approach.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00608
Abstract: The identification and characterization of novel triazolopyridine derivatives with selective α5 subunit-containing GABAA receptor negative allosteric modulator (NAM) activity are disclosed. As a result of in silico screening of our corporate compound deck, we identified… read more here.
Keywords: hybridization approach; gabaa receptor; receptor negative; identification ... See more keywords
Chemotherapy and Targeted Therapy for Patients With Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer That is Either Endocrine-Pretreated or Hormone Receptor–Negative: ASCO Guideline Update
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.21.01374
Abstract: PURPOSE This guideline updates recommendations of the ASCO guideline on chemotherapy and targeted therapy for patients with human epidermal growth factor receptor 2–negative metastatic breast cancer (MBC) that is either endocrine-pretreated or hormone receptor (HR)–negative.… read more here.
Keywords: chemotherapy; mbc; therapy; receptor negative ... See more keywords
Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0207776
Abstract: Regulation of transcription is a key process in cellular homeostasis. It depends on regulators that either repress or stimulate the transcription of genes, therefore controlling different biological functions. The Nuclear Receptor Corepressor 1 (NCOR1) is… read more here.
Keywords: hormone receptor; breast; lung adenocarcinomas; receptor negative ... See more keywords