Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y6
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DOI: 10.1002/cmdc.202100683
Abstract: Cyclooxygenase‐2 catalyzes the biosynthesis of prostaglandins from arachidonic acid and the biosynthesis of prostaglandin glycerol esters (PG‐Gs) from 2‐arachidonoylglycerol. PG‐Gs are mediators of several biological actions such as macrophage activation, hyperalgesia, synaptic plasticity, and intraocular… read more here.
Keywords: ester; receptor p2y6; mapping binding; p2y6 ... See more keywords
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02414-8
Abstract: Cyclooxygenase-2 catalyses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglandin glycerol esters (PG-Gs) from 2-arachidonoylglycerol. Previous studies identified PG-Gs as signalling molecules involved in inflammation. Thus, the glyceryl ester of… read more here.
Keywords: prostaglandin; receptor p2y6; pge2; receptor ... See more keywords