Deficiency of protease-activated receptor (PAR) 1 and PAR2 exacerbates collagen-induced arthritis in mice via differing mechanisms.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa701
Abstract: OBJECTIVES Protease-activated receptor (PAR) 1 and PAR2 have been implicated in RA, however their exact role is unclear. Here, we detailed the mechanistic impact of these receptors on the onset and development of inflammatory arthritis… read more here.
Keywords: par2; induced arthritis; receptor par; par par2 ... See more keywords
Plasma androgen receptor (pAR) status and activity of taxanes in metastatic castration resistant prostate cancer (mCRPC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.5074
Abstract: 5074Background: Plasma AR (pAR) gain identifies CRPC with worse outcome on abiraterone (abi) or enzalutamide (enza). We aimed to evaluate whether taxanes in CRPC are active regardless of AR status ... read more here.
Keywords: status; plasma; par; plasma androgen ... See more keywords
Protease-activated receptor-1 (PAR-1): a promising molecular target for cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21015
Abstract: PAR-1 is expressed not only in epithelium, neurons, astrocytes, immune cells, but also in cancer-associated fibroblasts, ECs (epithelial cells), myocytes of blood vessels, mast cells, and macrophages in tumor microenvironment, whereas PAR-1 stimulates macrophages to… read more here.
Keywords: par; receptor par; protease activated; activated receptor ... See more keywords