Articles with "receptor part" as a keyword



Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.

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Published in 2022 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.2c00400

Abstract: The diastereomeric macrocyclic calcitonin gene-related peptide (CGRP) antagonists HTL0029881 (3) and HTL0029882 (4), in which the stereochemistry of a spiro center is reversed, surprisingly demonstrate comparable potency. X-ray crystallographic characterization demonstrates that 3 binds to… read more here.

Keywords: macrocyclic antagonists; receptor part; antagonists cgrp; novel macrocyclic ... See more keywords