Patient Perspectives on Treatment Options for Older Women With Hormone Receptor–Positive Breast Cancer
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DOI: 10.1001/jamanetworkopen.2020.17129
Abstract: Key Points Question What are older women’s perspectives on recommendations for treatment de-escalation for low-risk, early-stage hormone receptor–positive breast cancer? Findings In this qualitative study of 30 participants aged 70 years or older, women expressed… read more here.
Keywords: hormone receptor; receptor positive; treatment; positive breast ... See more keywords
Association of Sperm-Associated Antigen 5 and Treatment Response in Patients With Estrogen Receptor–Positive Breast Cancer
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DOI: 10.1001/jamanetworkopen.2020.9486
Abstract: Key Points Question Are sperm-associated antigen 5 (SPAG5) transcript or protein expressions associated with treatment response in patients with estrogen receptor–positive breast cancer? Findings In this cohort study including 12 720 patients with estrogen receptor–positive breast… read more here.
Keywords: receptor positive; positive breast; spag5; breast cancer ... See more keywords
Association of Adjuvant Hormone Therapy Timing With Overall Survival Among Patients With Hormone Receptor–Positive Human Epidermal Growth Factor Receptor-2–Negative Early Breast Cancer Without Chemotherapy
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DOI: 10.1001/jamanetworkopen.2021.45934
Abstract: Key Points Question Is delayed adjuvant hormone therapy (AHT) associated with reduced survival in patients with hormone receptor–positive breast cancer? Findings In this cohort study of 144 103 US patients with hormone receptor–positive/human epidermal growth factor… read more here.
Keywords: survival; receptor positive; hormone receptor; breast cancer ... See more keywords
Author response to: Comment on: Meta‐analysis of the impact of progesterone receptor status on oncological outcomes in oestrogen receptor‐positive breast cancer
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DOI: 10.1002/bjs.11499
Abstract: *See Boland et al.1 for references. Hazard ratios are shown with 95 per cent confidence intervals. †Values in parentheses are standard errors. PgR–, progesterone receptor-negative; PgR+, progesterone receptor-positive; HER2–, HER2-negative; HER2+, HER2-positive. Author response to:… read more here.
Keywords: progesterone receptor; receptor positive; response comment; receptor ... See more keywords
Bridging the Age Gap: a prognostic model that predicts survival and aids in primary treatment decisions for older women with oestrogen receptor‐positive early breast cancer
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DOI: 10.1002/bjs.11748
Abstract: A prognostic model was developed and validated using cancer registry data. This underpins an online decision support tool, informing primary treatment choice for women aged 70 years or older with hormone receptor‐positive early breast cancer. read more here.
Keywords: positive early; early breast; receptor positive; prognostic model ... See more keywords
A multicenter phase II trial of neoadjuvant letrozole plus low‐dose cyclophosphamide in postmenopausal patients with estrogen receptor‐positive breast cancer (JBCRG‐07): therapeutic efficacy and clinical implications of circulating endothelial cells
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DOI: 10.1002/cam4.1516
Abstract: Neoadjuvant endocrine therapy has been reported to decrease tumor size, which leads to increased breast conservation rates. To improve the clinical response, metronomic chemotherapy with endocrine therapy is a promising strategy. A multicenter phase II… read more here.
Keywords: breast; receptor positive; positive breast; postmenopausal ... See more keywords
Buparlisib in combination with tamoxifen in pretreated patients with hormone receptor‐positive, HER2‐negative advanced breast cancer molecularly stratified for PIK3CA mutations and loss of PTEN expression
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DOI: 10.1002/cam4.3092
Abstract: The PIKTAM study evaluated the efficacy and safety of the PI3K inhibitor buparlisib in combination with tamoxifen in hormone receptor‐positive (HR+), HER2‐negative advanced breast cancer patients after failure of prior endocrine therapy. In this open‐label,… read more here.
Keywords: hormone receptor; positive her2; receptor positive; buparlisib combination ... See more keywords
Statin use in patients with hormone receptor‐positive metastatic breast cancer treated with everolimus and exemestane
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DOI: 10.1002/cam4.5369
Abstract: We analyzed the effect of statins in patients with hormone receptor‐positive (HR+) metastatic breast cancer treated with everolimus + exemestane (EverX). read more here.
Keywords: receptor positive; hormone receptor; positive metastatic; metastatic breast ... See more keywords
Endocrine therapy initiation and overall survival outcomes with omission of radiation therapy in older Medicare patients with early‐stage hormone‐receptor‐positive breast cancer
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DOI: 10.1002/cam4.5488
Abstract: Guidelines allow for the omission of radiotherapy in older women with early‐stage, hormone‐receptor‐positive breast cancer, given that the patients receive adequate endocrine therapy (ET). However, the initiation of ET and survival outcomes after forgoing radiation… read more here.
Keywords: stage hormone; early stage; receptor positive; hormone receptor ... See more keywords
A nomogram for predicting axillary pathologic complete response in hormone receptor–positive breast cancer with cytologically proven axillary lymph node metastases
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DOI: 10.1002/cncr.32830
Abstract: The objective of this study was to determine an axillary pathologic complete response (pCR) and its influencing factors in patients with hormone receptor (HR)–positive breast cancer and cytologically proven axillary lymph node metastases. A prediction… read more here.
Keywords: axillary pathologic; hormone receptor; receptor positive; pathologic complete ... See more keywords
Cost‐effectiveness of Choosing Wisely guidelines for axillary observation in women older than age 70 years with hormone receptor–positive, clinically node‐negative, operable breast tumors
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DOI: 10.1002/cncr.34207
Abstract: The Society for Surgical Oncology's Choosing Wisely guidelines recommend against sentinel lymph node biopsy (SLNB) in favor of observation in this population. Recent analyses reveal that this has not been widely adopted. The purpose of… read more here.
Keywords: receptor positive; hormone receptor; wisely guidelines; choosing wisely ... See more keywords