Comparison of the Human A2A Adenosine Receptor Recognition by Adenosine and Inosine: New Insight from Supervised Molecular Dynamics Simulations
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DOI: 10.1002/cmdc.201700200
Abstract: Adenosine deaminase converts adenosine into inosine. In contrast to adenosine, relatively little attention has been paid to the physiological roles of inosine. Nevertheless, recent studies have demonstrated that inosine has neuroprotective, cardioprotective, immunomodulatory, and antidepressive… read more here.
Keywords: adenosine inosine; a2a adenosine; adenosine receptor; receptor recognition ... See more keywords
Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry
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DOI: 10.1038/s41467-019-12346-8
Abstract: Despite extensive efforts on probing the mechanism of Alzheimer’s disease (AD) and enormous investments into AD drug development, the lack of effective disease-modifying therapeutics and the complexity of the AD pathogenesis process suggest a great… read more here.
Keywords: mass spectrometry; chirality regulated; mobility mass; recognition ... See more keywords
COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2
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DOI: 10.1371/journal.ppat.1008762
Abstract: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a newly emerging, highly transmissible, and pathogenic coronavirus in humans that has caused global public health emergencies and economic crises. To date, millions of infections and thousands of… read more here.
Keywords: receptor; sars cov; receptor recognition; host cell ... See more keywords