High Bone Mass From Mutation Of Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6).
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115550
Abstract: Wnt/β-catenin signaling is important for skeletal development and health. Eleven heterozygous gain-of-function missense mutations within the first β-propeller of low-density lipoprotein receptor-related protein 5 (LRP5) are known to cause the autosomal dominant disorder called high… read more here.
Keywords: receptor related; density lipoprotein; bone; low density ... See more keywords
Low-density lipoprotein receptor-related protein-1 (LRP1) targeting contrast-enhanced MRI as a novel strategy for epilepsy imaging
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103212
Abstract: a Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States b Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China c Center of Epilepsy, Beijing… read more here.
Keywords: epilepsy; receptor related; density lipoprotein; low density ... See more keywords
Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2016.10.029
Abstract: Parkinson's disease (PD) is one of the progressive neurodegenerative diseases of whose condition is characterized by dopaminergic neuronal cell loss and dysfunction in the substantia nigra pars compacta (SNpc) and the striatum. Recent studies have… read more here.
Keywords: receptor related; mptp induced; nuclear receptor; related protein ... See more keywords
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00392
Abstract: The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) is a promising target for the treatment of autoimmune diseases. A small molecule, inverse agonist of the receptor is anticipated to… read more here.
Keywords: acid receptor; inverse agonist; receptor related; retinoic acid ... See more keywords
The low density receptor-related protein 1 plays a significant role in ricin-mediated intoxication of lung cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65982-2
Abstract: Ricin, a highly lethal plant-derived toxin, is a potential biological threat agent due to its high availability, ease of production and the lack of approved medical countermeasures for post-exposure treatment. To date, no specific ricin… read more here.
Keywords: ricin; intoxication; receptor related; lrp1 ... See more keywords
Association of type 2 diabetes mellitus with the interaction between low‐density lipoprotein receptor‐related protein 5 (LRP5) polymorphisms and overweight and obesity in rural Chinese adults
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.12522
Abstract: Low‐density lipoprotein receptor‐related protein 5 (LRP5) plays an important role in glucose and cholesterol metabolism. The present cohort study evaluated associations of LRP5 variants with the incidence of type 2 diabetes mellitus (T2DM) in a… read more here.
Keywords: receptor related; density lipoprotein; low density; related protein ... See more keywords
Letter by Potere et al Regarding Article, "Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages".
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.118.036486
Abstract: April 16, 2019 1979 Nicola Potere, MD Stefano Toldo, PhD Antonio Abbate, MD, PhD To the Editor: We have read with interest the report by Mueller and colleagues1 suggesting that LRP1 (low-density lipoprotein receptor-related protein… read more here.
Keywords: receptor related; density lipoprotein; receptor; low density ... See more keywords
Low-Density Lipoprotein Receptor-Related Protein 6 Is Essential for Trophoblast Survival and Invasion
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive Sciences"
DOI: 10.1177/1933719118756773
Abstract: Remodeling of maternal spiral artery after the implantation of embryo relies on tightly regulated trophoblast functions and is pivotal to ensure the success of pregnancy. Low-density lipoprotein receptor-related protein 6 (LRP6) is implicated in angiogenesis… read more here.
Keywords: receptor related; lipoprotein receptor; trophoblast; related protein ... See more keywords
The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of endocrinology and metabolism"
DOI: 10.20945/2359-3997000000057
Abstract: OBJECTIVE The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. SUBJECTS AND METHODS A total number of… read more here.
Keywords: susceptibility; receptor related; density lipoprotein; lrp5 4037c ... See more keywords
Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.662460
Abstract: Background: Cancer patients are alleged to have poor coronavirus disease 2019 (COVID-19) outcomes. However, no systematic or comprehensive analyses of the role and mechanisms of COVID-19 receptor-related regulators in cancer are available. Methods: We comprehensively… read more here.
Keywords: related regulators; receptor related; coronavirus disease; cancer ... See more keywords
P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2022.876304
Abstract: Depression is a common psychiatric disorder and the leading cause of disability worldwide. Although treatments are available, only about 60% of treated patients experience a significant improvement in disease symptoms. Numerous clinical and rodent studies… read more here.
Keywords: p2x7 receptor; research; receptor related; mouse ... See more keywords