T Cell Receptor Repertoire Sequencing.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0904-0_1
Abstract: The status of T cell receptors (TCRs) repertoire is associated with the occurrence and progress of various diseases and can be used in monitoring the immune responses, predicting the prognosis of disease and other medical… read more here.
Keywords: cell receptor; repertoire sequencing; biology; repertoire ... See more keywords
T cell receptor repertoire as a potential diagnostic marker for celiac disease.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108621
Abstract: An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the… read more here.
Keywords: disease; cell receptor; celiac disease; receptor repertoire ... See more keywords
Antigen receptor repertoire profiling from RNA-seq data
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3979
Abstract: Somatic recombination and accumulation of mutations in V-D-J segments result in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1,2. High-throughput profiling of immune receptors has become an important tool for studies of adaptive immunity… read more here.
Keywords: profiling rna; repertoire profiling; rna seq; receptor ... See more keywords
Assessment of the T cell receptor repertoire in long‐term platelet donors by next generation sequencing
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.14576
Abstract: Temporary suppression of circulating antiplatelet alloantibodies by the massive infusion of fresh, stored, or lyophilized platelets. Transfusion, 18, 429–435. Narvios, A., Reddy, V., Martinez, F. & Lichtiger, B. (2005) Slow infusion of platelets: a possible… read more here.
Keywords: assessment cell; long term; repertoire long; cell receptor ... See more keywords
Application of T‐cell receptor repertoire as a novel monitor in dynamic tracking and assessment: A cohort‐study based on RA patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17623
Abstract: T‐cell receptor repertoire (TCRR) sequencing has been widely applied in many fields as a novel tool. This study explored characteristics of TCRR in detail with a cohort of 598 rheumatoid arthritis (RA) patients before and… read more here.
Keywords: cell receptor; receptor repertoire; tcrr;
TRUST4 Interrogates the Immune Receptor Repertoire in Oncology and Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0403
Abstract: The immune receptor repertoire is a set of cellular receptors responsible for recognizing foreign antigens. Characterizing the immune receptor repertoire is critical to understanding mechanisms of human adaptive immunity and developing new approaches to cancer… read more here.
Keywords: oncology; trust4 interrogates; immune receptor; receptor ... See more keywords
powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006571
Abstract: Sequencing of the T cell receptor (TCR) repertoire is a powerful tool for deeper study of immune response, but the unique structure of this type of data makes its meaningful quantification challenging. We introduce a… read more here.
Keywords: comparative analysis; cell receptor; model; repertoire ... See more keywords
Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01505
Abstract: Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung… read more here.
Keywords: betamethasone; changes cell; cell receptor; receptor repertoire ... See more keywords
A hierarchy of selection pressures determines the organization of the T cell receptor repertoire
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.939394
Abstract: We systematically examine the receptor repertoire in T cell subsets in young, adult, and LCMV-infected mice. Somatic recombination generates diversity, resulting in the limited overlap between nucleotide sequences of different repertoires even within the same… read more here.
Keywords: cell; selection pressures; hierarchy selection; repertoire ... See more keywords
B cell receptor repertoire analysis from autopsy samples of COVID-19 patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1034978
Abstract: Neutralizing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being developed world over. We investigated the possibility of producing artificial antibodies from the formalin fixation and paraffin-embedding (FFPE) lung lobes of a… read more here.
Keywords: analysis autopsy; artificial antibodies; repertoire analysis; cell receptor ... See more keywords