Engineering DNA Nanostructures to Manipulate Immune Receptor Signaling and Immune Cell Fates.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101844
Abstract: Immune cells sense, communicate, and logically integrate a multitude of environmental signals to make important cell-fate decisions and fulfill their effector functions. These processes are initiated and regulated by a diverse array of immune receptors… read more here.
Keywords: engineering; dna; dna nanostructures; receptor signaling ... See more keywords
Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable AMPA Receptor Currents and Drives Post‐Traumatic Epileptogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25698
Abstract: Traumatic brain injury is a major risk factor for acquired epilepsies, and understanding the mechanisms underlying the early pathophysiology could yield viable therapeutic targets. Growing evidence indicates a role for inflammatory signaling in modifying neuronal… read more here.
Keywords: toll like; epileptogenesis; like receptor; receptor signaling ... See more keywords
Hydrogen sulfide prevents arecoline‐induced neurotoxicity via promoting leptin/leptin receptor signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11850
Abstract: Arecoline, a major alkaloid of the areca nut, has potential toxicity to the nervous system. Our previous study reveals that the neurotoxicity of arecoline involves in inhibited endogenous hydrogen sulfide (H2S) generation. Therefore, the present… read more here.
Keywords: signaling pathway; arecoline induced; leptin receptor; receptor signaling ... See more keywords
Targeting the death receptor signaling pathway as a potential therapeutic target in the treatment of colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26640
Abstract: Despite advances in the diagnosis and treatment of colorectal cancer (CRC), it remains a major cause of cancer related death globally. There are currently no chemotherapeutic agents that have been found to eradicate the disease… read more here.
Keywords: death; death receptor; treatment; signaling pathway ... See more keywords
Leveraging β-Adrenergic Receptor Signaling Blockade for Improved Cancer Immunotherapy Through Biomimetic Nanovaccine.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207029
Abstract: The establishment of effective antitumor immune responses of vaccines is mainly limited by insufficient priming tumor infiltration of T cells and immunosuppressive tumor microenvironment (TME). Targeting β-adrenergic receptor (β-AR) signaling exerts promising benefits on reversing… read more here.
Keywords: biomimetic nanovaccine; receptor signaling; adrenergic receptor; tumor ... See more keywords
Understanding of B Cell Receptor Signaling Through a Photo-Activatable Antigen Presentation System.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_16
Abstract: Antibody responses are initiated by the binding of antigens to cell surface expressed B cell receptors (BCRs) that trigger signaling cascades resulting in the activation of B cells. However, it has been difficult to study… read more here.
Keywords: understanding cell; system; cell receptor; antigen ... See more keywords
Antidiabetic Properties of Low-Molecular-Weight BDNF Mimetics Depend on the Type of Activation of Post-Receptor Signaling Pathways
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4069-y
Abstract: Reduced proliferation and enhanced apoptosis of β cells in diabetes mellitus are associated with a deficiency of brain-derived neurotrophic factor (BDNF). Low-molecular weight compounds similar to different BDNF loops were synthesized at the V. V.… read more here.
Keywords: signaling pathways; post receptor; low molecular; molecular weight ... See more keywords
Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Nephrology"
DOI: 10.1007/s40620-017-0432-8
Abstract: Toll-like receptors (TLRs) are a class of receptors of the innate immune system which detect pathogen-associated and danger-associated molecular patterns in order to initiate an inflammatory response. TLR2 and TLR4 downward signaling causes the production… read more here.
Keywords: toll like; signaling mediates; like receptor; diabetic nephropathy ... See more keywords
CD34+ hematopoietic stem cells are mobilized with exercise independently of beta-2 adrenergic receptor signaling
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.07.087
Abstract: A single exercise bout mobilizes CD34+ hematopoietic stem cells (HSCs) to the bloodstream, potentially serving as an economical adjuvant to boost the collection of HSCs from stem cell transplant donors. The mechanisms responsible for HSC… read more here.
Keywords: stem; receptor signaling; receptor; adrenergic receptor ... See more keywords
Oridonin is an antidepressant molecule working through the PPAR-γ/AMPA receptor signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114136
Abstract: Oridonin is a diterpene compound that regulates the activity of PPAR-γ (peroxisome proliferator-activated receptor gamma) transcription factor. Cumulative evidence indicates that AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) play an important role in the treatment… read more here.
Keywords: ppar; treatment; ampa receptor; receptor signaling ... See more keywords
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.04.031
Abstract: SUMMARY PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade.… read more here.
Keywords: signaling pathways; pathways regulating; interferon; expression ... See more keywords