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Published in 2018 at "Molecular and Cellular Neurosciences"
DOI: 10.1016/j.mcn.2018.07.003
Abstract: &NA; We have synthesized a novel small molecule based on the pyrrolidinone–containing core structure of clausenamide, which is a candidate anti–dementia drug. The synthetic route yielded multi–gram quantities of an isomeric racemate mixture in a…
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Keywords:
receptor signalling;
small molecule;
ampa receptor;
physiological signature ... See more keywords
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Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.04.009
Abstract: Toll-like receptors (TLRs) are the sensors of pathogen-associated molecules that trigger tailored innate immune intracellular signalling responses to initiate innate immune reactions. Data from the experimental autoimmune encephalomyelitis (EAE) model indicates that TLR signalling machinery…
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Keywords:
like receptor;
toll like;
multiple sclerosis;
receptor signalling ... See more keywords
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Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0931-2
Abstract: Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative disease, such as cancer, as a result of their deregulated expression or mutation. Unlike other tyrosine kinases that have been clinically targeted,…
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Keywords:
receptor signalling;
non catalytic;
eph receptor;
eph receptors ... See more keywords
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Published in 2019 at "Nature"
DOI: 10.1038/s41586-018-0832-5
Abstract: Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and are common substances…
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Keywords:
receptor signalling;
pharmacology;
gabaa receptor;
microscopy ... See more keywords
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Published in 2019 at "International immunology"
DOI: 10.1093/intimm/dxz024
Abstract: Autoinflammatory syndromes are a group of disorders characterised by recurring episodes of inflammation as a result of specific defects in the innate immune system. Patients with autoinflammatory disease present with recurrent outbreaks of chronic systemic…
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Keywords:
receptor signalling;
signalling autoinflammatory;
tnf receptor;
autoinflammatory diseases ... See more keywords
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Published in 2022 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2021.2764
Abstract: Insect wing polyphenism has evolved as an adaptation to changing environments and a growing body of research suggests that the nutrient-sensing insulin receptor signalling pathway is a hot spot for the evolution of polyphenisms, as…
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Keywords:
polyphenism water;
polyphenism;
receptor signalling;
wing polyphenism ... See more keywords
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Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14057
Abstract: Dopamine has multiple anti‐inflammatory effects, but its role and molecular mechanism in acute pancreatitis (AP) are unclear. We investigated the role of dopamine signalling in the inflammatory response in AP.
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Keywords:
acute pancreatitis;
receptor signalling;
pancreatitis;
controls inflammation ... See more keywords
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Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15066
Abstract: Biased agonism describes the ability of ligands to differentially regulate multiple signalling pathways when coupled to a single receptor. Signalling is affected by rapid agonist‐induced receptor internalisation. Hence, the conventional use of equilibrium models may…
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Keywords:
receptor signalling;
evaluation profiles;
profiles cb1;
cb1 cannabinoid ... See more keywords
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Published in 2018 at "Reproduction"
DOI: 10.1530/rep-18-0423
Abstract: Our understanding of G protein-coupled receptor (GPCR) signalling has significantly evolved over the past decade, whereby signalling not only occurs from the plasma membrane but continues, or is reactivated, following internalisation in to endosomal compartments.…
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Keywords:
receptor signalling;
hormone receptor;
role;
receptor ... See more keywords