Three mutations switch H7N9 influenza to human-type receptor specificity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006390
Abstract: The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously… read more here.
Keywords: receptor specificity; human type; influenza; h7n9 ... See more keywords
Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.827760
Abstract: Humans can be infected by zoonotic avian, pandemic and seasonal influenza A viruses (IAVs), which differ by receptor specificity and conformational stability of their envelope glycoprotein hemagglutinin (HA). It was shown that receptor specificity of… read more here.
Keywords: receptor specificity; infection; iavs; conformational stability ... See more keywords
Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022
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DOI: 10.3390/pathogens11111388
Abstract: The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the… read more here.
Keywords: receptor specificity; h3n2; influenza; 2a1b h3n2 ... See more keywords
Receptor Specificity Engineering of TNF Superfamily Ligands
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DOI: 10.3390/pharmaceutics14010181
Abstract: The tumor necrosis factor (TNF) ligand family has nine ligands that show promiscuity in binding multiple receptors. As different receptors transduce into diverse pathways, the study on the functional role of natural ligands is very… read more here.
Keywords: specificity engineering; tnf; receptor specificity; specificity ... See more keywords