Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells
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DOI: 10.1038/s41598-021-81164-0
Abstract: Prostate cancer (PCa) is dependent on the androgen receptor (AR). Advanced PCa is treated with an androgen deprivation therapy-based regimen; tumors develop resistance, although they typically remain AR-dependent. Expression of constitutively active AR variants lacking… read more here.
Keywords: receptor splice; splice variant; androgen receptor; prostate cancer ... See more keywords
Abstract 2266: Detection of androgen receptor splice variants from clinical sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2266
Abstract: Background: Androgen receptor splice variant-7 (AR-v7) has been widely studied as a biomarker of resistance to AR-targeted therapy in castration-resistant prostate cancer (CRPC). Various methods have been used to detect AR-v7 in CRPC specimens, including… read more here.
Keywords: detection; cancer; androgen receptor; receptor splice ... See more keywords