Feasibility of olanzapine, multi acting receptor targeted antipsychotic agent, for the prevention of emesis caused by continuous cisplatin- or ifosfamide-based chemotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0487-3
Abstract: SummaryBackground To determine the feasibility and efficacy of olanzapine, which is approved by the Pharmaceuticals and Medical Devices Agency as multi acting receptor targeted antipsychotic agent of the thienobenzodiazepine class, for prevention of chemotherapy-induced nausea… read more here.
Keywords: chemotherapy; targeted antipsychotic; receptor targeted; acting receptor ... See more keywords
Intraoperative Molecular Imaging Utilizing a Folate Receptor-Targeted Near-Infrared Probe Can Identify Macroscopic Gastric Adenocarcinomas
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-020-01549-x
Abstract: Purpose Current methods of assessing disease burden in gastric adenocarcinoma are imperfect. Improved visualization during surgery with intraoperative molecular imaging (IMI) could improve gastric adenocarcinoma staging and guide surgical decision-making. The goal of this study… read more here.
Keywords: intraoperative molecular; receptor targeted; folate receptor; molecular imaging ... See more keywords
Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2016.08.027
Abstract: Background: The ability to provide safe and effective pharmacotherapy during obstetric complications, such as preterm labor or postpartum hemorrhage, is hampered by the systemic toxicity of therapeutic agents leading to adverse side effects in the… read more here.
Keywords: drug delivery; receptor targeted; targeted liposomes; receptor ... See more keywords
Design and Application of Receptor-Targeted Fluorescent Probes Based on Small Molecular Fluorescent Dyes.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00606
Abstract: In recent years, a variety of receptor-targeted fluorescent probes have been developed and widely used to realize the visualization of certain receptors, which facilitates the early diagnosis and treatment of diseases. In this Review, we… read more here.
Keywords: targeted fluorescent; application receptor; receptor targeted; fluorescent probes ... See more keywords
Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69682-9
Abstract: Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDCs with varying… read more here.
Keywords: crosslinking agent; dna crosslinking; dna; folate ... See more keywords
Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Materials Chemistry Frontiers"
DOI: 10.1039/c6qm00227g
Abstract: To construct biocompatible imaging nanoprobes and apply them to receptor-specific targeting of breast cancers is of great significance for precise diagnosis and personalized therapy serving nanomedicine. Herein, hybrid polymeric methylene blue-embedded nanoprobes (PBCA-MB@CS-FA) for folate… read more here.
Keywords: hybrid polymeric; photoacoustic imaging; receptor targeted; targeted photoacoustic ... See more keywords
Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201443119
Abstract: Significance Atherosclerosis underpins the progression of stroke and myocardial infarction, both leading causes of death globally. Gene therapy is an emerging therapeutic approach for atherosclerosis, but the delivery of gene cargoes to the atherosclerotic plaque… read more here.
Keywords: targeted plaque; receptor targeted; atherosclerosis; scavenger receptor ... See more keywords
Efficacy of Androgen Receptor-targeted Drugs After Prostate Cancer Recurrence With Bone Metastases: PROSTAT-BSI Sub-analysis
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15798
Abstract: Background/Aim: This study aimed to evaluate the therapeutic benefit of novel androgen receptor-targeted agents (ARTAs) in castration-resistant prostate cancer (CRPC) with bone metastases in Japan. Patients and Methods: In followup to our prospective observational study… read more here.
Keywords: receptor targeted; androgen receptor; recurrence; prostate cancer ... See more keywords
Toll-like receptor-targeted anti-tumor therapies: Advances and challenges
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1049340
Abstract: Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to stimulate innate immune reactions against microbial infection. TLRs also play essential roles in bridging the innate and adaptive immune system, playing multiple roles in inflammation,… read more here.
Keywords: toll like; receptor targeted; like receptor; tlr targeted ... See more keywords
Receptor-Targeted Glial Brain Tumor Therapies
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19113326
Abstract: Among primary brain tumors, malignant gliomas are notably difficult to manage. The higher-grade tumors represent an unmet need in medicine. There have been extensive efforts to implement receptor-targeted therapeutic approaches directed against gliomas. These approaches… read more here.
Keywords: glial brain; receptor targeted; targeted glial; brain ... See more keywords