Combinatorial siRNA Polyplexes for Receptor Targeting.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9220-1_7
Abstract: As synthetic small interfering RNA (siRNA) against antitumoral gene targets show promise for cancer treatment, different siRNA delivery systems have sparkled intense investigations. To develop tumor-specific carriers for cytosolic and systemic siRNA delivery, our laboratory… read more here.
Keywords: combinatorial sirna; receptor targeting; sirna polyplexes; polyplexes receptor ... See more keywords
Radioiodinated Ethinylestradiol Derivatives for Estrogen Receptor Targeting Breast Cancer Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00559
Abstract: Two novel PEGylated ethinylestradiol (PEG = poly(ethylene glycol)) estrogen receptor (ER) targeting probes [131I]EITE and [131I]MITE were synthesized and evaluated. Both probes had a nanomolar binding affinity to the ER receptor (36.47 nM for [131I]EITE… read more here.
Keywords: breast; 131i eite; estrogen receptor; 131i mite ... See more keywords
Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteins
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52685-9
Abstract: Targeted protein degradation has emerged as a novel therapeutic modality to treat human diseases by utilizing the cell’s own disposal systems to remove protein target. Significant clinical benefits have been observed for degrading many intracellular… read more here.
Keywords: receptor; cancer; degradation; receptor targeting ... See more keywords
A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02230c
Abstract: A receptor-targeting AIE photosensitizer (CE-TPA) is synthesized by conjugating cephalothin with a cationic D-A type AIE photosensitizer for selective killing of Gram-positive bacteria over Gram-negative bacteria and normal mammalian cells. By virtue of the strong… read more here.
Keywords: aie photosensitizer; targeting aie; photosensitizer selective; real time ... See more keywords
Abstract IA017: Transferrin receptor targeting chimeras (TransTACs) for targeted degradation of membrane and extracellular proteins in cancer
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.cancerchem24-ia017
Abstract: The membrane and extracellular proteome plays central roles in health and disease. Harnessing TfR1, a constitutive, rapidly internalizing receptor overexpressed in a broad spectrum of cancers, we developed Transferrin Receptor Targeting Chimeras (TransTACs) for targeted… read more here.
Keywords: receptor; cancer; receptor targeting; membrane extracellular ... See more keywords
The real-world benefit of novel androgen receptor-targeting agents (ARTA) before and after docetaxel in CRPC with bone metastases in Japan: A subanalysis of the PROSTAT-BSI, a prospective observational study before and after approval of novel ARTAs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.6_suppl.43
Abstract: 43Background: ARTAs (enzalutamide and abiraterone) have been approved for relapse of prostate cancer in Japan since 2014. However, the efficacy of ARTAs for overall survival (OS) has not yet been p... read more here.
Keywords: receptor targeting; world benefit; benefit novel; novel androgen ... See more keywords
Two receptor-targeting mechanisms of lambda-like siphophage Gifsy-1 of Salmonella Typhimurium
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1013352
Abstract: The receptor-targeting mechanisms by which λ-like siphophages establish infection in gram-negative bacteria remain poorly characterized. This study demonstrated that the λ-like phage Gifsy-1, which exhibits broad lytic activity in Salmonella enterica, employs two receptor-targeting mechanisms… read more here.
Keywords: receptor targeting; receptor; salmonella typhimurium; targeting mechanisms ... See more keywords
Estrogen receptor α (ERα )-targeting compounds and derivatives: Recent advances in structural modification and bioactivity.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666190619142504
Abstract: Breast cancer is the most common cancer suffered by female, and the second highest cause of cancer-related death among women worldwide. At present, hormone therapy is still the main treatment route and can be divided… read more here.
Keywords: estrogen; receptor targeting; targeting compounds; cancer ... See more keywords
Nanoparticle-mediated active and passive drug targeting in oral squamous cell carcinoma: current trends and advances.
Sign Up to like & getrecommendations! Published in 2024 at "Nanomedicine"
DOI: 10.2217/nnm-2023-0247
Abstract: Oral squamous cell carcinoma (OSCC) is an invasive and highly malignant cancer with significant morbidity and mortality. Existing treatments including surgery, chemotherapy and radiation have poor overall survival rates and prognosis. The intended therapeutic effects… read more here.
Keywords: receptor; receptor targeting; oral squamous; squamous cell ... See more keywords
Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.38366
Abstract: In the light of theranostics/radiotheranostics and prospective of personalized medicine in diabetes and oncology, this review presents prior and current advances in the development of radiolabeled imaging and radiotherapeutic exendin-based agents targeting glucagon-like peptide-1 receptor.… read more here.
Keywords: advances glp; theranostics advances; receptor targeting; receptor ... See more keywords