A novel Epstein–Barr virus-latent membrane protein-1-specific T-cell receptor for TCR gene therapy
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Cancer"
DOI: 10.1038/bjc.2017.475
Abstract: Background:Adoptive transfer of genetically engineered T-cells to express antigen-specific T-cell receptor (TCR) is a feasible and effective therapeutic approach for numerous types of cancers, including Epstein–Barr virus (EBV)-associated malignancies. Here, we describe a TCR gene… read more here.
Keywords: epstein barr; receptor tcr; specific cell; cell receptor ... See more keywords
T cell receptor (TCR) signaling in health and disease
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DOI: 10.1038/s41392-021-00823-w
Abstract: Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways… read more here.
Keywords: signal transduction; disease; cell; receptor tcr ... See more keywords
Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005845
Abstract: Immunotherapy strategies aim to mobilize immune defenses against tumor cells by targeting mainly T cells. Co‐inhibitory receptors or immune checkpoints (ICPs) (such as PD-1 and CTLA4) can limit T cell receptor (TCR) signal propagation in… read more here.
Keywords: cell receptor; tcr signaling; receptor tcr; immunotherapy ... See more keywords