Charting protein dephosphorylation triggered by Toll-like receptor (TLR) signaling in macrophages and its role in health and disease.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.02.003
Abstract: Toll-like receptor (TLR) signaling induces substantial changes in the phosphoproteome of innate immune cells, mainly in the form of increased phosphorylation of signaling intermediaries. Loss of constitutive phosphorylation occurs simultaneously, but these transitions from a… read more here.
Keywords: toll like; like receptor; tlr signaling; receptor tlr ... See more keywords
2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00643
Abstract: A novel series of 2,4-diaminoquinazolines was identified as potent dual Toll-like receptor (TLR) 7 and 8 agonists with reduced off-target activity. The stereochemistry of the amino alcohol was found to influence the TLR7/8 selectivity with… read more here.
Keywords: receptor tlr; toll like; dual toll; like receptor ... See more keywords
Extracellular Cardiolipin Modulates Select Immune Functions of Astrocytes in Toll-Like Receptor (TLR) 4-Dependent Manner
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/9946439
Abstract: Alzheimer's disease (AD) is characterized by chronic neuroinflammation, which is partially mediated by dysregulated functions of glial cells. Cardiolipin (CL) is a phospholipid normally confined to the inner mitochondrial membrane; however, it has been detected… read more here.
Keywords: toll like; receptor tlr; like receptor; tlr dependent ... See more keywords