In the fast lane: Receptor trafficking during status epilepticus
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12718
Abstract: Status epilepticus (SE) remains a significant cause of morbidity and mortality and often is refractory to standard first‐line treatments. A rapid loss of synaptic inhibition and development of pharmacoresistance to benzodiazepines (BZDs) occurs early during… read more here.
Keywords: receptor trafficking; receptor; ampa; status epilepticus ... See more keywords
Quantitative Analysis of Membrane Receptor Trafficking Manipulated by Optogenetic Tools.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1258-3_2
Abstract: Membrane receptors play a crucial role in transmitting external signals inside cells. Signal molecule-bound receptors activate multiple downstream pathways, the dynamics of which are modulated by intracellular trafficking. A significant contribution of β-arrestin to intracellular… read more here.
Keywords: trafficking; quantitative analysis; receptor trafficking; membrane receptor ... See more keywords
Alteration of NMDA receptor trafficking as a cellular hallmark of psychosis
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01549-7
Abstract: A dysfunction of the glutamatergic transmission, especially of the NMDA receptor (NMDAR), constitutes one of the main biological substrate of psychotic disorders, such as schizophrenia. The NMDAR signaling hypofunction, through genetic and/or environmental insults, would… read more here.
Keywords: trafficking cellular; nmda receptor; alteration nmda; cellular hallmark ... See more keywords
Targeting GLP-1 receptor trafficking to improve agonist efficacy
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03941-2
Abstract: Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important pharmacological target in type 2 diabetes (T2D). Like other G protein-coupled receptors, the GLP-1R undergoes agonist-mediated endocytosis,… read more here.
Keywords: agonist; targeting glp; efficacy; receptor trafficking ... See more keywords
CaMello-XR enables visualization and optogenetic control of Gq/11 signals and receptor trafficking in GPCR-specific domains
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0292-y
Abstract: The signal specificity of G protein-coupled receptors (GPCRs) including serotonin receptors (5-HT-R) depends on the trafficking and localization of the GPCR within its subcellular signaling domain. Visualizing traffic-dependent GPCR signals in neurons is difficult, but… read more here.
Keywords: ca2 signals; gpcr; receptor trafficking; localization ... See more keywords
Retrieval-extinction of drug memory requires AMPA receptor trafficking
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add6642
Abstract: Disruption of drug-associated memory reduces relapse. Transient memory retrieval facilitates the upcoming extinction of addiction memory, while the neural basis for this beneficial outcome remains unelucidated. Here, we report that AMPA receptor trafficking acts as… read more here.
Keywords: retrieval extinction; receptor trafficking; ampa receptor; memory ... See more keywords
An autism-associated mutation in GluN2B prevents NMDA receptor trafficking and interferes with dendrite growth
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.232892
Abstract: ABSTRACT Autism spectrum disorders (ASDs) are neurodevelopmental disorders with multiple genetic associations. Analysis of de novo mutations identified GRIN2B, which encodes the GluN2B subunit of NMDA receptors, as a gene linked to ASDs with high… read more here.
Keywords: glun2b; nmda receptor; autism; grin2b mutations ... See more keywords
Impaired Glycine Receptor Trafficking in Neurological Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00291
Abstract: Ionotropic glycine receptors (GlyRs) enable fast synaptic neurotransmission in the adult spinal cord and brainstem. The inhibitory GlyR is a transmembrane glycine-gated chloride channel. The immature GlyR protein undergoes various processing steps, e.g., folding, assembly,… read more here.
Keywords: startle disease; life cycle; glyr; receptor trafficking ... See more keywords
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.25492
Abstract: The subunit composition of synaptic NMDA receptors (NMDAR), such as the relative content of GluN2A- and GluN2B-containing receptors, greatly influences the glutamate synaptic transmission. Receptor co-agonists, glycine and D-serine, have intriguingly emerged as potential regulators… read more here.
Keywords: glun2b; nmdar; agonists differentially; serine ... See more keywords