Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13054-3
Abstract: The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we… read more here.
Keywords: capsaicin receptor; trpv1; receptor trpv1; acetaminophen ... See more keywords