Glucosylsphingosine evokes pruritus via activation of 5-HT2A receptor and TRPV4 in sensory neurons.
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DOI: 10.1111/bph.15733
Abstract: BACKGROUND AND PURPOSE Glucosylsphingosine (GS), an endogenous sphingolipid, is highly accumulated in the epidermis of patients with atopic dermatitis (AD) due to abnormal ceramide metabolism. More importantly, GS can evoke scratching behaviors. However, the precise… read more here.
Keywords: receptor; receptor trpv4; sensory neurons; ht2a receptor ... See more keywords