Zebrafish and medaka T1R (taste receptor type 1) proteins mediate highly sensitive recognition of l‐proline
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13558
Abstract: In vertebrates, nutritional tastants, such as amino acids and sugars, are recognized by G‐protein‐coupled receptors of the taste receptor type 1 (T1R) family. Previous studies have shown that fish T1Rs are functionally distinct from mammalian… read more here.
Keywords: taste receptor; zebrafish medaka; highly sensitive; proline ... See more keywords
Myotonic dystrophy kinase‐related CDC42‐binding kinase α, a new transferrin receptor type 2‐binding partner, is a regulator of erythropoiesis
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26104
Abstract: Efficient erythropoiesis relies on the expression of the transferrin receptor type 2 (TFR2). In erythroid precursors, TFR2 facilitates the export of the erythropoietin receptor (EPOR) to cell surface, which ensures the survival and proliferation of… read more here.
Keywords: kinase; transferrin receptor; receptor type; myotonic dystrophy ... See more keywords
Detection of activin receptor type IIA and IIB-Fc fusion proteins by automated capillary immunoassay.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3378
Abstract: Activin receptor type IIA and type IIB fusion protein have been designed to sequester circulating molecules of the TGF-β superfamily and inactivate their actions. Members of this superfamily have been reported as essential regulators of… read more here.
Keywords: fusion; type iia; activin receptor; detection ... See more keywords
Carbohydrate recognition of C3-symmetrical tripodal receptor-type 2,4,6-trisubstituted 1,3,5-triazine derivatives with antiviral activities
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-018-7573-4
Abstract: In our search for new bioactive compounds that interfere with the sugar recognition process, we have designed and synthesized C3- and Cs-symmetrical tripodal receptor-type molecules. Among the synthesized C3-symmetrical 2,4,6-trisubstituted 1,3,5-triazine (TAZ) derivatives, compounds A… read more here.
Keywords: symmetrical tripodal; trisubstituted triazine; recognition; receptor type ... See more keywords
Angiotensin II receptor type 1 - an update on structure, expression and pathology.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114673
Abstract: The AT1 receptor, a major effector of the renin-angiotensin system, has been extensively studied in the context of cardiovascular and renal disease. Moreover, angiotensin receptor blockers, sartans, are among the most frequently prescribed drugs for… read more here.
Keywords: pathology; angiotensin receptor; receptor type; structure ... See more keywords
P113 High levels of angiotensin receptor type 1 antibodies in a child with FSGS who had a renal transplant
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.173
Abstract: Focal Segmental Glomerulosclerosis (FSGS) can lead to ESRD requiring a renal transplant and the rate of recurrent FSGR (rFSGS) is high. The exact mechanisms of the pathogenesis of FSGS and rFSGS is unclear and both… read more here.
Keywords: transplant; angiotensin receptor; receptor type; renal transplant ... See more keywords
High prevalence of rare ryanodine receptor type 1 variants in patients suffering from aneurysmatic subarachnoid hemorrhage: A pilot study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2017.06.029
Abstract: Subarachnoid hemorrhage (SAH) remains a challenging neurosurgical disease. The ryanodine receptor type 1 Ca2+ channel (RyR1) plays a crucial role in vasoconstriction and hemostasis. Mutations of the encoding gene, RYR1, are known to cause susceptibility… read more here.
Keywords: subarachnoid hemorrhage; ryr1; prevalence; receptor type ... See more keywords
Generation of an Aptamer Targeting Receptor-Type Tyrosine-Protein Phosphatase F.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03988
Abstract: Cell-SELEX is a powerful tool to generate aptamers that specifically bind the native molecules on living cells. Here, we report an aptamer ZAJ4a generated by cell-SELEX. The molecular target of ZAJ4a was pulled down by… read more here.
Keywords: cell; type tyrosine; cell selex; protein phosphatase ... See more keywords
Structure-Based Design, Optimization, and Development of [18F]LU13: A Novel Radioligand for Cannabinoid Receptor Type 2 Imaging in the Brain with PET.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00256
Abstract: The cannabinoid receptor type 2 (CB2R) is an attractive target for the diagnosis and therapy of neurodegenerative diseases and cancer. In this study, we aimed at the development of a novel 18F-labeled radioligand starting from… read more here.
Keywords: pet; cannabinoid receptor; 18f lu13; radioligand ... See more keywords
Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2038448
Abstract: ABSTRACT microRNAs, as small endogenous RNAs, influence umpteen sophisticated cellular biological functions regarding neurodegenerative and cerebrovascular diseases. Here, we interrogated miR-381-3p’s influence on BV2 activation and neurotoxicity in ischemic and hypoxic environment. Oxygen-glucose deprivation (OGD)… read more here.
Keywords: damage; expression; mir 381; receptor type ... See more keywords
Melatonin receptor type 1A gene linked to Alzheimer’s disease in old age
Sign Up to like & getrecommendations! Published in 2018 at "Sleep"
DOI: 10.1093/sleep/zsy103
Abstract: Abstract Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer’s disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer’s disease. Previously, we have reported… read more here.
Keywords: type gene; alzheimer disease; disease; receptor type ... See more keywords