Allosteric modulation of G protein‐coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?
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DOI: 10.1002/med.21633
Abstract: The function of G protein‐coupled receptors (GPCRs) can be modulated by compounds that bind to other sites than the endogenous orthosteric binding site, so‐called allosteric sites. Structure elucidation of a number of GPCRs has revealed… read more here.
Keywords: amiloride analogs; receptors amiloride; protein coupled; coupled receptors ... See more keywords