Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective
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DOI: 10.1021/acs.jmedchem.9b00220
Abstract: The spread of antibiotic resistance is one of the most serious global public-health problems. Here we show that a particular class of homomers with binding sites spanning multiple protein chains is particularly suitable for targeting… read more here.
Keywords: design; structural characteristics; receptors broad; common structural ... See more keywords