Articles with "receptors degradation" as a keyword



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Abstract IA30: Targeting hormone receptors for degradation: Nuclear receptor downregulation as a therapeutic approach in cancer

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Published in 2017 at "Clinical Cancer Research"

DOI: 10.1158/1557-3265.pmccavuln16-ia30

Abstract: Durable clinical responses to endocrine therapies in breast cancer are limited by the development of resistance that can occur as a consequence of estrogen receptor–alpha (ERα) mutations, the production of non-canonical ER ligands, or to… read more here.

Keywords: receptors degradation; downregulation; hormone receptors; cancer ... See more keywords