Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.03.014
Abstract: In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here… read more here.
Keywords: affinity; human pancreatic; gabaa receptors; gaba ... See more keywords
Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology
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DOI: 10.1371/journal.ppat.1008647
Abstract: A trimeric glycoprotein complex on the surface of human cytomegalovirus (HCMV) binds to platelet-derived growth factor (PDGF) receptor α (PDGFRα) to mediate host cell recognition and fusion of the viral and cellular membranes. Soluble PDGFRα… read more here.
Keywords: hcmv; human biology; human cytomegalovirus; engineered receptors ... See more keywords
Ergotamine Stimulates Human 5-HT4-Serotonin Receptors and Human H2-Histamine Receptors in the Heart
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054749
Abstract: Ergotamine (2′-methyl-5′α-benzyl-12′-hydroxy-3′,6′,18-trioxoergotaman) is a tryptamine-related alkaloid from the fungus Claviceps purpurea. Ergotamine is used to treat migraine. Ergotamine can bind to and activate several types of 5-HT1-serotonin receptors. Based on the structural formula of ergotamine,… read more here.
Keywords: ht4 serotonin; histamine receptors; receptors human; serotonin receptors ... See more keywords