Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01651
Abstract: Medicinal chemists are accountable for embedding the appropriate drug target profile into the molecular architecture of a clinical candidate. An accurate characterization of the functional effects following binding of a drug to its biological target… read more here.
Keywords: membrane bound; receptors insights; drug; modalities membrane ... See more keywords
Non-genomic effects of nuclear receptors: insights from the anucleate platelet
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvy044
Abstract: Abstract Nuclear receptors (NRs) have the ability to elicit two different kinds of responses, genomic and non-genomic. Although genomic responses control gene expression by influencing the rate of transcription, non-genomic effects occur rapidly and independently… read more here.
Keywords: nuclear receptors; effects nuclear; receptors insights; genomic effects ... See more keywords