New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3* Nicotinic Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01372
Abstract: A three-dimensional database search has been applied to design a series of endo- and exo-3-(pyridin-3-yl)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor ligands. The synthesized compounds were tested in radioligand binding assay on rat cortex against [3H]-cytisine and [3H]-methyllycaconitine… read more here.
Keywords: rigid nicotine; new rigid; nicotinic receptors; receptors new ... See more keywords
Death Receptors: New Opportunities in Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Acta Naturae"
DOI: 10.32607/20758251-2017-9-3-55-63
Abstract: This article offers a detailed review of the current approaches to anticancer therapy that target the death receptors of malignant cells. Here, we provide a comprehensive overview of the structure and function of death receptors… read more here.
Keywords: death; death receptors; receptors new; therapy ... See more keywords