Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.06.042
Abstract: Toll-like receptors (TLRs) are pattern recognition receptors which mediate an inflammatory response upon the detection of specific molecular patterns found on foreign organisms and on endogenous damage-related molecules. These receptors play a major role in… read more here.
Keywords: like receptors; toll like; receptors therapeutic; parkinson disease ... See more keywords
Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00643
Abstract: The endogenous neuropeptide FF (NPFF) and its two cognate G protein-coupled receptors, Neuropeptide FF Receptors 1 and 2 (NPFFR1 and NPFFR2), represent a relatively new target system for many therapeutic applications including pain regulation, modulation… read more here.
Keywords: therapeutic applications; receptors therapeutic; npffr ligands; applications ligand ... See more keywords
Eicosanoid receptors as therapeutic targets for asthma.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical science"
DOI: 10.1042/cs20190657
Abstract: Eicosanoids comprise a group of oxidation products of arachidonic and 5,8,11,14,17-eicosapentaenoic acids formed by oxygenases and downstream enzymes. The two major pathways for eicosanoid formation are initiated by the actions of 5-lipoxygenase (5-LO), leading to… read more here.
Keywords: therapeutic targets; targets asthma; receptors therapeutic; eicosanoid receptors ... See more keywords
P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00222
Abstract: Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel. Therefore, salivary gland dysfunction… read more here.
Keywords: receptors therapeutic; dysfunction; therapeutic targets; physiology ... See more keywords