Novel approach to incorporate information about recessive lethal genes increases the accuracy of genomic prediction for mortality traits
Sign Up to like & getrecommendations! Published in 2020 at "Heredity"
DOI: 10.1038/s41437-020-0329-5
Abstract: The genetic underpinnings of calf mortality can be partly polygenic and partly due to deleterious effects of recessive lethal alleles. Prediction of the genetic merits of selection candidates should thus take into account both genetic… read more here.
Keywords: risk; novel approach; accuracy; mortality ... See more keywords
PCR-RFLP assays to detect recessive lethal alleles in Landrace and Duroc pigs in Vietnam
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DOI: 10.1177/10406387251318022
Abstract: Increasing the number of live-born piglets per litter is one of the major objectives of pig breeding programs. Single nucleotide polymorphisms (SNPs) in polynucleotide kinase-phosphatase (PNKP), RNA polymerase I subunit B (POLR1B), ribosome biogenesis (URB1),… read more here.
Keywords: recessive lethal; lethal alleles; duroc pigs; rflp ... See more keywords
The population genetics of human disease: The case of recessive, lethal mutations
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DOI: 10.1371/journal.pgen.1006915
Abstract: Do the frequencies of disease mutations in human populations reflect a simple balance between mutation and purifying selection? What other factors shape the prevalence of disease mutations? To begin to answer these questions, we focused… read more here.
Keywords: genetics; disease; selection; recessive lethal ... See more keywords