Design of Cyclic Peptides as Protein Recognition Motifs.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9504-2_6
Abstract: Protein-protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Linear peptide drugs, however, can be applied therapeutically as protein recognition motifs only to a limited extent… read more here.
Keywords: protein recognition; design cyclic; recognition motifs; peptides protein ... See more keywords
Cholesterol-Recognition Motifs in Membrane Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-14265-0_1
Abstract: The impact of cholesterol on the structure and function of membrane proteins was recognized several decades ago, but the molecular mechanisms underlying these effects have remained elusive. There appear to be multiple mechanisms by which… read more here.
Keywords: motifs membrane; membrane proteins; cholesterol; recognition motifs ... See more keywords
Multicolor Iridium(III) Complexes with Host-Guest Recognition Motifs for Enhanced Electrochemiluminescence and Modular Labeling.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05698
Abstract: Cyclometalated Ir(III) complexes with high electrochemiluminescence (ECL) efficiency and appropriate bioconjugation sites are urgently needed in ECL immunoassays (ECLIA). Herein, we report the synthesis, photophysics, electrochemistry, and ECL of six new Ir(III) complexes bearing naphthyl… read more here.
Keywords: host guest; guest recognition; iii complexes; iii ... See more keywords
Cancer-Associated Substitutions in RNA Recognition Motifs of PUF60 and U2AF65 Reveal Residues Required for Correct Folding and 3′ Splice-Site Selection
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12071865
Abstract: U2AF65 (U2AF2) and PUF60 (PUF60) are splicing factors important for recruitment of the U2 small nuclear ribonucleoprotein to lariat branch points and selection of 3′ splice sites (3′ss). Both proteins preferentially bind uridine-rich sequences upstream… read more here.
Keywords: puf60; selection; recognition motifs; puf60 u2af65 ... See more keywords
Comparative analyses of the thermodynamic RNA binding signatures of different types of RNA recognition motifs
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.3929/ethz-a-007586428
Abstract: RNA recognition motifs (RRMs) are structurally versatile domains important in regulation of alternative splicing. Structural mechanisms of sequence-specific recognition of single-stranded RNAs (ssRNAs) by RRMs are well understood. The thermodynamic strategies are however unclear. Therefore,… read more here.
Keywords: thermodynamics; rna binding; recognition motifs; recognition ... See more keywords