Co-translational Folding Intermediate Dictates Membrane Targeting of the Signal Recognition Particle Receptor.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.04.017
Abstract: Much of our knowledge on the function of proteins is deduced from their mature, folded states. However, it is unknown whether partially synthesized nascent protein segments can execute biological functions during translation and whether their… read more here.
Keywords: signal recognition; membrane targeting; recognition particle; particle receptor ... See more keywords
Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010448
Abstract: Establishing a catalog of Congenital Heart Disease (CHD) genes and identifying functional networks would improve our understanding of its oligogenic underpinnings. Our studies identified protein biogenesis cofactors Nascent polypeptide-Associated Complex (NAC) and Signal-Recognition-Particle (SRP) as… read more here.
Keywords: recognition particle; associated complex; nascent polypeptide; heart ... See more keywords
Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
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DOI: 10.2169/internalmedicine.0404-22
Abstract: A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness… read more here.
Keywords: recognition particle; mrna 1273; anti signal; antibody ... See more keywords
Signal Recognition Particle in Human Diseases
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DOI: 10.3389/fgene.2022.898083
Abstract: The signal recognition particle (SRP) is a ribonucleoprotein complex with dual functions. It co-translationally targets proteins with a signal sequence to the endoplasmic reticulum (ER) and protects their mRNA from degradation. If SRP is depleted… read more here.
Keywords: human diseases; particle human; signal recognition; recognition particle ... See more keywords