A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators.
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DOI: 10.1016/j.ceca.2019.02.007
Abstract: Mutation of a single residue within the recently identified lipid (diacylglycerol) recognition window of TRPC3 (G652A) was found to abolish channel activation via endogenous lipid mediators while retaining sensitivity to the non-lipid activator GSK1702934A (abb.… read more here.
Keywords: channel; trpc3; mutation; recognition window ... See more keywords