Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1).
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DOI: 10.1016/j.ajog.2020.08.004
Abstract: BACKGROUND Despite expectant management, preeclampsia remote from term usually results in preterm delivery. Antithrombin displays anti-inflammatory and anticoagulant properties and thus may have a therapeutic role treating preterm preeclampsia, a disorder characterized by endothelial dysfunction,… read more here.
Keywords: antithrombin; preterm preeclampsia; recombinant antithrombin; placebo ... See more keywords
The efficacy and associated bleeding complications of recombinant antithrombin supplementation among intensive care unit patients.
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DOI: 10.1016/j.thromres.2017.06.035
Abstract: INTRODUCTION The aim of this study was to evaluate the efficacy and complications of recombinant antithrombin (rAT) supplementation for adult patients with disseminated intravascular coagulation (DIC) compared with conventional plasma derived AT (pAT) treatment in… read more here.
Keywords: supplementation; intensive care; group; rat group ... See more keywords
Newly Developed Recombinant Antithrombin Protects the Endothelial Glycocalyx in an Endotoxin-Induced Rat Model of Sepsis
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DOI: 10.3390/ijms22010176
Abstract: (1) Background: The endothelial glycocalyx is a primary target during the early phase of sepsis. We previously reported a newly developed recombinant non-fucosylated antithrombin has protective effects in vitro. We further evaluated the effects of… read more here.
Keywords: high dose; dose group; group; recombinant antithrombin ... See more keywords