Vaccination with a CD4+ and CD8+ T‐cell epitopes‐based recombinant chimeric protein derived from Leishmania infantum proteins confers protective immunity against visceral leishmaniasis
Sign Up to like & getrecommendations! Published in 2018 at "Translational Research"
DOI: 10.1016/j.trsl.2018.05.001
Abstract: &NA; Vaccination seems to be the best approach to control visceral leishmaniasis (VL). Resistance against infection is based on the development of a Th1 immune response characterized by the production of interferons‐&ggr; (IFN‐&ggr;), interleukin‐12 (IL‐12),… read more here.
Keywords: cell epitopes; recombinant chimeric; visceral leishmaniasis; based recombinant ... See more keywords
A recombinant chimeric protein of protective antigen and lethal factor from Bacillus anthracis in polymeric nanocapsules showed a strong immune response in mice: a potential high efficacy vaccine against anthrax.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2022.68.3.1
Abstract: Anthrax is a serious infectious disease caused by Bacillus anthracis, rod-shaped gram-positive bacteria. The disease infects both humans and animals and causes severe illness. Many vaccines have been developed for anthrax, but the vaccine with… read more here.
Keywords: recombinant chimeric; bacillus anthracis; immune response; mice ... See more keywords
Recombinant and Chimeric Disintegrins in Preclinical Research
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DOI: 10.3390/toxins10080321
Abstract: Disintegrins are a family of small cysteine-rich peptides, found in a wide variety of snake venoms of different phylogenetic origin. These peptides selectively bind to integrins, which are heterodimeric adhesion receptors that play a fundamental… read more here.
Keywords: disintegrins preclinical; chimeric disintegrins; recombinant chimeric; preclinical research ... See more keywords
Single Dose of Recombinant Chimeric Horsepox Virus (TNX-801) Vaccination Protects Macaques from Lethal Monkeypox Challenge
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DOI: 10.3390/v15020356
Abstract: The ongoing global Monkeypox outbreak that started in the spring of 2022 has reinforced the importance of protecting the population using live virus vaccines based on the vaccinia virus (VACV). Smallpox also remains a biothreat… read more here.
Keywords: recombinant chimeric; single dose; tnx 801; chimeric horsepox ... See more keywords
A Recombinant Chimeric Protein-Based Vaccine Containing T-Cell Epitopes from Amastigote Proteins and Combined with Distinct Adjuvants, Induces Immunogenicity and Protection against Leishmania infantum Infection
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10071146
Abstract: Currently, there is no licensed vaccine to protect against human visceral leishmaniasis (VL), a potentially fatal disease caused by infection with Leishmania parasites. In the current study, a recombinant chimeric protein ChimT was developed based… read more here.
Keywords: recombinant chimeric; cell; chimt; immunogenicity ... See more keywords