A mathematical model of a recombinant humanized anti‐cocaine monoclonal antibody’s effects on cocaine pharmacokinetics in mice
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.07.006
Abstract: Aims A recombinant humanized anti‐cocaine monoclonal antibody (mAb), h2E2, is at an advanced stage of pre‐clinical development as an immunotherapy for cocaine abuse. It is hypothesized that h2E2 binds to and sequesters cocaine in the… read more here.
Keywords: humanized anti; antibody; model; recombinant humanized ... See more keywords
A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Its Metabolites in Rats
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DOI: 10.1124/dmd.118.083857
Abstract: A recombinant humanized anticocaine monoclonal antibody, h2E2, has shown potential in the preclinical phases for the treatment of cocaine abuse. The standard tests for cocaine usage are the detection of benzoylecgonine (BE) and cocaine in… read more here.
Keywords: cocaine; humanized anticocaine; recombinant humanized; presence h2e2 ... See more keywords
Recombinant Humanized IgG1 Antibody Protects against oxLDL-Induced Oxidative Stress and Apoptosis in Human Monocyte/Macrophage THP-1 Cells by Upregulation of MSRA via Sirt1-FOXO1 Axis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911718
Abstract: Oxidized low-density lipoprotein (oxLDL)-induced oxidative stress and apoptosis are considered as critical contributors to cardiovascular diseases. Methionine sulfoxide reductase A (MSRA) is a potent intracellular oxidoreductase and serves as an essential factor that protects cells… read more here.
Keywords: oxidative stress; recombinant humanized; humanized igg1; msra ... See more keywords