Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38.
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DOI: 10.1016/j.cellimm.2017.01.003
Abstract: LMB-2, is a potent recombinant immunotoxin (RIT) that is composed of scFv antibody that targets CD25 (Tac) and a toxin fragment (PE38). It is used to treat T cell leukemias and lymphomas. To make LMB-2… read more here.
Keywords: recombinant immunotoxin; lmb 142; cell epitopes; point mutations ... See more keywords