Growth of doxorubicin‐resistant undifferentiated spindle‐cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26527
Abstract: Undifferentiated spindle‐cell sarcoma (USCS) is a recalcitrant cancer in need of individualized therapy. A high‐grade USCS from a striated muscle of a patient was grown orthotopically in the right biceps femoris muscle of nude mice… read more here.
Keywords: recombinant methioninase; spindle cell; cell sarcoma; pdox ... See more keywords
Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates.
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DOI: 10.1007/978-1-4939-8796-2_16
Abstract: Methionine (MET) is a general metabolic therapeutic target in cancer, whereby cancer cells have an elevated requirement for MET, termed MET dependence. We have developed recombinant L-methionine α-deamino-γ-mercaptomethane lyase (recombinant methioninase [rMETase, EC 4.4.1.11]) as… read more here.
Keywords: megc peg; peg rmetase; toxicity; recombinant methioninase ... See more keywords
The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model
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DOI: 10.1007/s00280-019-03986-0
Abstract: Purpose Cancers are methionine (MET) and methylation addicted, causing them to be highly sensitive to MET restriction. The present study determined the efficacy of restricting MET with oral-recombinant methioninase (o-rMETase) and the DNA methylation inhibitor,… read more here.
Keywords: chemotherapy; combination; oral recombinant; chemotherapy resistant ... See more keywords
Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.024
Abstract: Cancer cells are methionine (MET) and methylation addicted and are highly sensitive to MET restriction. The present study determined the efficacy of oral-recombinant methioninase (o-rMETase) and the DNA methylation inhibitor, decitabine (DAC) on restricting MET… read more here.
Keywords: combination; oral recombinant; tissue sarcoma; soft tissue ... See more keywords
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.016
Abstract: Recombinant methioninase (rMETase) was previously administered as an injectable drug to target methionine dependence of cancer. Recently, we observed that rMETase could be administered orally (o-rMETase) in a patient-derived orthotopic xenograft (PDOX) mouse model of… read more here.
Keywords: methioninase rmetase; pancreatic cancer; resistance; recombinant methioninase ... See more keywords
Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention
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DOI: 10.1080/15384101.2017.1405195
Abstract: ABSTRACT The elevated methionine (MET) use by cancer cells is termed MET dependence and may be the only known general metabolic defect in cancer. Targeting MET by recombinant methioninase (rMETase) can arrest the growth of… read more here.
Keywords: melanoma; therapy; recombinant methioninase; pdox ... See more keywords
Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model
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DOI: 10.21873/anticanres.12899
Abstract: Background/Aim: Synovial sarcoma (SS) is a recalcitrant neoplasm with low chemosensitivity. We recently reported that recombinant methioninase (rMETase) inhibited SS growth in a patient-derived orthotopic xenograft (PDOX) mouse model and was more effective when administered… read more here.
Keywords: doxorubicin; pdox; model; recombinant methioninase ... See more keywords