Stable recombinant production of codon‐scrambled lubricin and mucin in human cells
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26940
Abstract: Widespread therapeutic and commercial interest in recombinant mucin technology has emerged due to the unique ability of mucin glycoproteins to hydrate, protect, and lubricate biological surfaces. However, recombinant production of the large, highly repetitive domains… read more here.
Keywords: production; mucin; recombinant production; stable recombinant ... See more keywords
Recombinant Production of Monomeric Isotope-Enriched Aggregation-Prone Peptides: Polyglutamine Tracts and Beyond.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0524-0_10
Abstract: High solvent exposure of certain sequences located in intrinsically disordered regions (IDRs) may eventually lead to aggregation, as is the case for some low-complexity regions (LCRs) and short linear motifs (SLiMs). In particular, polyglutamine (polyQ)… read more here.
Keywords: isotope enriched; aggregation; production monomeric; recombinant production ... See more keywords
Recombinant Production and Intein-Mediated Purification of an Antimicrobial Peptide, BR2
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-017-9583-7
Abstract: Nowadays, targeted therapy of cancer is under intensive focus of many investigations due to severe side effects imposed by various cancer chemotherapeutics. BR2 is a modified antimicrobial cell penetrating peptide with confirmed capability of delivering… read more here.
Keywords: peptide; br2; recombinant production; purification ... See more keywords
Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective NaV1.7 inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114148
Abstract: Chronic pain is a common and often debilitating condition. Existing treatments are either inefficacious or associated with a wide range of side effects. The progress on developing safer and more effective analgesics has been slow,… read more here.
Keywords: inhibitor; recombinant production; membrane binding; membrane ... See more keywords
The role of Antibody Vκ Framework 3 region towards Antigen binding: Effects on recombinant production and Protein L binding
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02756-3
Abstract: Antibody research has traditionally focused on heavy chains, often neglecting the important complementary role of light chains in antibody formation and secretion. In the light chain, the complementarity-determining region 3 (VL-CDR3) is specifically implicated in… read more here.
Keywords: framework region; antigen binding; recombinant production; antibody ... See more keywords
Recombinant production of a diffusible signal factor inhibits Salmonella invasion and animal carriage
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2208498
Abstract: ABSTRACT The complex chemical environment of the intestine is defined largely by the metabolic products of the resident microbiota. Enteric pathogens, elegantly evolved to thrive in the gut, use these chemical products as signals to… read more here.
Keywords: salmonella invasion; diffusible signal; recombinant production; salmonella ... See more keywords
The next generation of protein super‐fibres: robust recombinant production and recovery of hagfish intermediate filament proteins with fibre spinning and mechanical–structural characterizations
Sign Up to like & getrecommendations! Published in 2021 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.13869
Abstract: Native hagfish intermediate filament proteins have impressive mechanical properties. However, using these native fibres for any application is impractical, necessitating their recombinant production. In the only literature report on the proteins (denoted α and ɣ),… read more here.
Keywords: intermediate filament; hagfish intermediate; recombinant production; filament proteins ... See more keywords
Getting value from the waste: recombinant production of a sweet protein by Lactococcus lactis grown on cheese whey
Sign Up to like & getrecommendations! Published in 2018 at "Microbial Cell Factories"
DOI: 10.1186/s12934-018-0974-z
Abstract: BackgroundRecent biotechnological advancements have allowed for the adoption of Lactococcus lactis, a typical component of starter cultures used in food industry, as the host for the production of food-grade recombinant targets. Among several advantages, L.… read more here.
Keywords: lactis; production; cheese whey; recombinant production ... See more keywords