Recombinant Tissue Plasminogen Activator-conjugated Nanoparticles Effectively Targets Thrombolysis in a Rat Model of Middle Cerebral Artery Occlusion
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DOI: 10.1007/s11596-018-1896-z
Abstract: SummaryThe efficacy and safety of recombinant tissue plasminogen activator (rtPA) need to be improved due to its low bioavailability and requirement of large dose administration. The purpose of this study was to develop a fibrin-targeted… read more here.
Keywords: plasminogen activator; tissue plasminogen; recombinant tissue; rtpa ... See more keywords
Preparation of thermosensitive magnetic liposome encapsulated recombinant tissue plasminogen activator for targeted thrombolysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Magnetism and Magnetic Materials"
DOI: 10.1016/j.jmmm.2016.10.122
Abstract: Abstract Recombinant tissue plasminogen activator (rtPA) was encapsulated in thermosensitive magnetic liposome (TML) prepared from 1,2-dipalmitoyl- sn -glycero-3-phosphocholine, distearolyphosphatidyl ethanolamine- N -poly(ethylene glycol) 2000, cholesterol and Fe 3 O 4 magnetic nanoparticles by solvent evaporation/sonication… read more here.
Keywords: magnetic liposome; drug; thermosensitive magnetic; recombinant tissue ... See more keywords
Use of recombinant tissue plasminogen activator for treatment of recalcitrant anterior uveitis: A case series
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Taibah University Medical Sciences"
DOI: 10.1016/j.jtumed.2018.03.005
Abstract: Management of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective… read more here.
Keywords: anterior uveitis; inflammation; recalcitrant anterior; recombinant tissue ... See more keywords
Controversies in cerebrovascular disease: high or low doses of recombinant tissue plasminogen activator to treat acute stroke? A literature review
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DOI: 10.1016/j.nrleng.2018.04.002
Abstract: Abstract Introduction The use of low doses of recombinant tissue plasminogen activator (rt-PA) was initially proposed in Asian countries in response to racial peculiarities related to the functionality of fibrinogen and coagulation factors that potentially… read more here.
Keywords: use; doses recombinant; acute stroke; recombinant tissue ... See more keywords
Effect of the interaction between atrial fibrillation and rt-PA dose on the prognosis of acute ischaemic stroke with intravenous thrombolysis
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DOI: 10.1136/postgradmedj-2022-141710
Abstract: Background The association between atrial fibrillation (AF) and the prognosis of acute ischaemic stroke (AIS) remains controversial; whether the recombinant tissue plasminogen activator dose influences this association remains poorly understood. Methods Patients who had an… read more here.
Keywords: tissue plasminogen; plasminogen activator; recombinant tissue;
Effect of the interaction between atrial fibrillation and rt-PA dose on the prognosis of acute ischaemic stroke with intravenous thrombolysis.
Sign Up to like & getrecommendations! Published in 2022 at "Postgraduate medical journal"
DOI: 10.1136/postmj/postgradmedj-2022-141710
Abstract: BACKGROUND The association between atrial fibrillation (AF) and the prognosis of acute ischaemic stroke (AIS) remains controversial; whether the recombinant tissue plasminogen activator dose influences this association remains poorly understood. METHODS Patients who had an… read more here.
Keywords: tissue plasminogen; plasminogen activator; recombinant tissue;
Successful thrombolytic therapy with recombinant tissue plasminogen activator in ischemic stroke after idarucizumab administration for reversal of dabigatran: a case report
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DOI: 10.1186/s13256-019-2326-y
Abstract: BackgroundIdarucizumab is a specific antidote for the anticoagulant dabigatran. Although its efficacy has been recently reported, the drug is still in postmarketing surveillance and requires case data in different emergency settings. A newer intravenous thrombolytic… read more here.
Keywords: therapy; plasminogen activator; tissue plasminogen; recombinant tissue ... See more keywords
The Utility of Automated ASPECTS in Acute Ischemic Stroke for Intravenous Recombinant Tissue Plasminogen Activator (IV-rtPA) Therapy
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DOI: 10.3390/neurolint14040077
Abstract: Purpose: This study aimed to investigate the accuracy and clinical significance of an artificial intelligence (AI)-based automated Alberta Stroke Program Early Computed Tomography (ASPECT) scoring software of head CT for the indication of intravenous recombinant… read more here.
Keywords: software; tissue plasminogen; therapy; recombinant tissue ... See more keywords